Structure of PDB 7ujv Chain B

Receptor sequence

>7ujvB (length=219) Species: 9606 (Homo sapiens) [Search protein sequence]

LPALKLALEYIVPCMNKHGICVVDDFLGKETGQQIGDEVRALHDTGKFTD
GQLVSQKSDSSKDIRGDKITWIEGKEPGCETIGLLMSSMDDLIRHCNGKL
GSYKINGRTKAMVACYPGNGTGYVRHVDNPNGDGRCVTCIYYLNKDWDAK
VSGGILRIFPEGKAQFADIEPKFDRLLFFWSDRRNPHEVQPAYATRYAIT
VWYFDADERARAKVKYLTG

3D structure

PDB

7ujv Structure of PHD2 in complex with HIF2a-CODD

Chain

Resolution

1.8 Å

3D
structure

[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]

Enzymatic activity

Enzyme Commision number

1.14.11.29: hypoxia-inducible factor-proline dioxygenase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	peptide	B	Q239 L240 V241 S242 I251 R252 W258 D277 R281 N293 G294 R295 K297 Y310 H313 D315 P317 N318 R322 W389 Y390 F391 R396 K400 Y403	Q52 L53 V54 S55 I64 R65 W71 D90 R94 N106 G107 R108 K110 Y123 H126 D128 P130 N131 R135 W202 Y203 F204 R209 K213 Y216
BS02	FE	B	H313 D315 H374	H126 D128 H187

Gene Ontology

	Molecular Function
GO:0005506	iron ion binding
GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
GO:0031418	L-ascorbic acid binding

View graph for
Molecular Function

External links

PDB	RCSB:7ujv, PDBe:7ujv, PDBj:7ujv
PDBsum	7ujv
PubMed	38418569
UniProt	Q9GZT9\|EGLN1_HUMAN Egl nine homolog 1 (Gene Name=EGLN1)

[Back to BioLiP]