Structure of PDB 7ujq Chain B

Receptor sequence

>7ujqB (length=268) Species: 9606 (Homo sapiens)

TRFTEEYQLFEELGKGAFSVVRRCVKVLAGQEYAAKIINTKKLSARDHQK
LEREARICRLLKHPNIVRLHDSISEEGHHYLIFDLVTGGELFEDIVAREY
YSEADASHCIQQILEAVLHCHQMGVVHRNLKPENLLLASKLKGAAVKLAD
FGLAIEVEGEQQAWFGFAGTPGYLSPEVLRKDPYGKPVDLWACGVILYIL
LVGYPPFWDEDQHRLYKQIKAGAYDFPSPEWDTVTPEAKDLINKMLTINP
SKRITAAEALKHPWISHR

3D structure

• PDB: 7ujq CaMKII binds both substrates and activators at the active site.
• Chain: B
• Resolution: 2.25 Å

Enzymatic activity

• Enzyme Commision number: 2.7.11.17: calcium/calmodulin-dependent protein kinase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	peptide	B	G22 A23 F24 E216	G16 A17 F18 E210
BS02	peptide	B	R52 K56 E96 F98 E99 N135 K137 E139 F173 A174 G175 T176 P177 G178 Y210 W214 P233 E236	R46 K50 E90 F92 E93 N129 K131 E133 F167 A168 G169 T170 P171 G172 Y204 W208 P227 E230
BS03	UZD	B	A40 F89 D90 L91 V92 D156	A34 F83 D84 L85 V86 D150

Gene Ontology

Molecular Function

• GO:0004672 protein kinase activity
• GO:0005524 ATP binding

Biological Process

• GO:0006468 protein phosphorylation

External links

• PDB: RCSB:7ujq, PDBe:7ujq, PDBj:7ujq
• PDBsum: 7ujq
• PubMed: 35830796
• UniProt: Q9UQM7|KCC2A_HUMAN Calcium/calmodulin-dependent protein kinase type II subunit alpha (Gene Name=CAMK2A)