Structure of PDB 7ujp Chain B

Receptor sequence

>7ujpB (length=267) Species: 9606 (Homo sapiens)

TRFTEEYQLFEELGKGAFSVVRRCVKVLAGQEYAAKIINTKKLSARDHQK
LEREARICRLLKHPNIVRLHDSISEEGHHYLIFDLVTGGELFEDIVAREY
YSEADASHCIQQILEAVLHCHQMGVVHRNLKPENLLLASKLKGAAVKLAD
FGLAIEVEGEQQAWFGFAGTPGYLSPEVLRKDPYGKPVDLWACGVILYIL
LVGYPPFWDEDQHRLYKQIKAGAYDFPSPEWDTVTPEAKDLINKMLTINP
SKRITAAEALKHPWISH

3D structure

• PDB: 7ujp CaMKII binds both substrates and activators at the active site.
• Chain: B
• Resolution: 2.56 Å

Enzymatic activity

• Enzyme Commision number: 2.7.11.17: calcium/calmodulin-dependent protein kinase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	peptide	B	G22 A23 F24 K48 D53 Q218	G16 A17 F18 K42 D47 Q212
BS02	peptide	B	E96 F98 E99 N135 E139 L159 F173 A174 G175 T176 P177 G178 Y210 P211 Q218 E236	E90 F92 E93 N129 E133 L153 F167 A168 G169 T170 P171 G172 Y204 P205 Q212 E230
BS03	ATP	B	A40 V92 K137 N140 L142 D156	A34 V86 K131 N134 L136 D150
BS04	MG	B	E139 D156	E133 D150

Gene Ontology

Molecular Function

• GO:0004672 protein kinase activity
• GO:0005524 ATP binding

Biological Process

• GO:0006468 protein phosphorylation

External links

• PDB: RCSB:7ujp, PDBe:7ujp, PDBj:7ujp
• PDBsum: 7ujp
• PubMed: 35830796
• UniProt: Q9UQM7|KCC2A_HUMAN Calcium/calmodulin-dependent protein kinase type II subunit alpha (Gene Name=CAMK2A)