Structure of PDB 7uj4 Chain B

Receptor sequence
>7uj4B (length=447) Species: 9606 (Homo sapiens) [Search protein sequence]
GLKTAQKTLFPLRSIDDVVRLFAAELGREEPDLVLLSLVLGFVEHFLAVN
RVGGLTYFPVADLSIIAALYARFTAQIRGAVDLSLYPREGGVSSRELVKK
VSDVIWNSLSRSYFKDRAHIQSLFSFITGTKLDSSGVAFAVVGACQALGL
RDVHLALSEDHAWVVFGPNGEQTAEVTWHGRGQTVNAGVAERSWLYLKGS
YMRCDRKMEVAFMVCAINPSIDLHTDSLELLQLQQKLLWLLYDLGHLERY
PMALGNLADLEELEPTPGRPDPLTLYHKGIASAKTYYRDEHIYPYMYLAG
YHCRNRNVREALQAWADTATVIQDYNYCREDEEIYKEFFEVANDVIPNLL
KEAASLLEAGSALQDPECFAHLLRFYDGICKWEEGSPTPVLHVGWATFLV
QSLGRFEGQVRQKVRITFQSEKMKGMKELLVATKINSSAIKLQLTAQ
3D structure
PDB7uj4 MEN1 mutations mediate clinical resistance to menin inhibition.
ChainB
Resolution1.96 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 OQ4 B S155 S178 E179 H181 A182 F238 C241 A242 Y276 M278 Y319 M322 Y323 G326 W341 E363 V367 S135 S158 E159 H161 A162 F212 C215 A216 Y250 M252 Y293 M296 Y297 G300 W315 E337 V341
BS02 MG B D180 E359 D160 E333
Gene Ontology

View graph for
Cellular Component
External links
PDB RCSB:7uj4, PDBe:7uj4, PDBj:7uj4
PDBsum7uj4
PubMed36922589
UniProtO00255|MEN1_HUMAN Menin (Gene Name=MEN1)

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