Structure of PDB 7uiz Chain B

Receptor sequence

>7uizB (length=580) Species: 562 (Escherichia coli) [Search protein sequence]

ENFTTNLNQLARVGGIDPLIGREKELERAIQVLCRRRKNNPLLVGESGVG
KTAIAEGLAWRIVQGDVPEVMADCTIYSLDIGSLLAGTKYRGDFEKRFKA
LLKQLEQDTNSILFIDEIHTIIGAGAASGGQVDAANLIKPLLSSGKIRVI
GSTTYQEFSNIFEKDRALARRFQKIDITEPSIEETVQIINGLKPKYEAHH
DVRYTAKAVRAAVELAVKYINDRHLPDKAIDVIDEAGARARLMPVSKRKK
TVNVADIESVVARIARIPEKSVSQSDRDTLKNLGDRLKMLVFGQDKAIEA
LTEAIKMARAGLGHEHKPVGSFLFAGPTGVGKTEVTVQLSKALGIELLRF
DMSEYMERHTVSRLIGAPPGYVGFDQGGLLTDAVIKHPHAVLLLDEIEKA
HPDVFNILLQVMDNGTLTDNNGRKADFRNVVLVMTTNAGVRETERKSIGL
IHQDNSTDAMEEIKKIFTPEFRNRLDNIIWFDHLSTDVIHQVVDKFIVEL
QVQLDQKGVSLEVSQEARNWLAEKGYDRAMGARPMARVIQDNLKKPLANE
LLFGSLVDGGQVTVALDKEKNELTYGFQSA

3D structure

PDB

7uiz AAA+ protease-adaptor structures reveal altered conformations and ring specialization.

Chain

Resolution

3.24 Å

3D
structure

[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]

Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	peptide	B	K258 Y259 R260 A296 S297 R527 H528 G539 Y540 V541	K89 Y90 R91 A127 S128 R358 H359 G370 Y371 V372
BS02	AGS	B	S216 G219 K220 T221 A222 I357 L361 D396 I399	S47 G50 K51 T52 A53 I188 L192 D227 I230
BS03	AGS	B	L459 F461 T497 G498 V499 G500 K501 T502 E503 N606 K664 R702	L290 F292 T328 G329 V330 G331 K332 T333 E334 N437 K495 R533

Gene Ontology

	Molecular Function
GO:0004176	ATP-dependent peptidase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016887	ATP hydrolysis activity

	Biological Process
GO:0006508	proteolysis
GO:0006515	protein quality control for misfolded or incompletely synthesized proteins
GO:0006979	response to oxidative stress
GO:0034605	cellular response to heat
GO:0043335	protein unfolding

	Cellular Component
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0009368	endopeptidase Clp complex

View graph for
Molecular Function

View graph for
Biological Process

View graph for
Cellular Component

External links

PDB	RCSB:7uiz, PDBe:7uiz, PDBj:7uiz
PDBsum	7uiz
PubMed	36329286
UniProt	P0ABH9\|CLPA_ECOLI ATP-dependent Clp protease ATP-binding subunit ClpA (Gene Name=clpA)

[Back to BioLiP]