Structure of PDB 7uir Chain B

Receptor sequence
>7uirB (length=261) Species: 9606 (Homo sapiens) [Search protein sequence]
TRFTEEYQLFEELGKGAFSVVRRCVKVLAGQEYAAKIINTSARDHQKLER
EARICRLLKHPNIVRLHDSISEEGHHYLIFDLVTGGELFEDIVAREYYSE
ADASHCIQQILEAVLHCHQMGVVHRNLKPENLLLASGAAVKLADFGLAIE
VEGEQQAWFGFAGTPGYLSPEVLRKDPYGKPVDLWACGVILYILLVGYPP
FWDEDQHRLYKQIKAGAYDFPSPEWDTVTPEAKDLINKMLTINPSKRITA
AEALKHPWISH
3D structure
PDB7uir CaMKII binds both substrates and activators at the active site.
ChainB
Resolution3.1 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.11.17: calcium/calmodulin-dependent protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide B E216 D217 Q218 Y222 E204 D205 Q206 Y210
BS02 peptide B F98 E105 K137 E139 G175 T176 G178 Y179 V208 G209 Y210 W214 P233 E236 F89 E96 K128 E130 G163 T164 G166 Y167 V196 G197 Y198 W202 P221 E224
BS03 ATP B G22 V27 A40 K42 V92 E96 L142 D156 G16 V21 A34 K36 V83 E87 L133 D144
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:7uir, PDBe:7uir, PDBj:7uir
PDBsum7uir
PubMed35830796
UniProtQ9UQM7|KCC2A_HUMAN Calcium/calmodulin-dependent protein kinase type II subunit alpha (Gene Name=CAMK2A)

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