Structure of PDB 7uiq Chain B

Receptor sequence
>7uiqB (length=261) Species: 9606 (Homo sapiens) [Search protein sequence]
RFTEEYQLFEELGKGAFSVVRRCVKVLAGQEYAAKIINTSARDHQKLERE
ARICRLLKHPNIVRLHDSISEEGHHYLIFDLVTGGELFEDIVAREYYSEA
DASHCIQQILEAVLHCHQMGVVHRNLKPENLLLASKLAAVKLADFGLAIE
VEGEQQAWFGFAGTPGYLSPEVLRKDPYGKPVDLWACGVILYILLVGYPP
FWDEDQHRLYKQIKAGAYDFPSPEWDTVTPEAKDLINKMLTINPSKRITA
AEALKHPWISH
3D structure
PDB7uiq CaMKII binds both substrates and activators at the active site.
ChainB
Resolution3.11 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.11.17: calcium/calmodulin-dependent protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide B E216 D217 Q218 Y222 E204 D205 Q206 Y210
BS02 peptide B E96 F98 E99 E105 K137 E139 F173 G175 T176 V208 G209 Y210 W214 P233 E236 E86 F88 E89 E95 K127 E129 F161 G163 T164 V196 G197 Y198 W202 P221 E224
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:7uiq, PDBe:7uiq, PDBj:7uiq
PDBsum7uiq
PubMed35830796
UniProtQ9UQM7|KCC2A_HUMAN Calcium/calmodulin-dependent protein kinase type II subunit alpha (Gene Name=CAMK2A)

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