Structure of PDB 7ugl Chain B

Receptor sequence
>7uglB (length=115) Species: 9606 (Homo sapiens) [Search protein sequence]
KIFKPEELRQALMPTLEALYRQDPESLPFRQPVDPQLLGIPDYFDIVKNP
MDLSTIKRKLDTGQYQEPWQYVDDVWLMFNNAWLYNRKTSRVYKFCSKLA
EVFEQEIDPVMQSLG
3D structure
PDB7ugl Structural basis of CBP and EP300 interaction with kinase inhibitors
ChainB
Resolution1.5 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.3.1.-
2.3.1.48: histone acetyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 N6I B R1091 Q1092 M1095 P1096 E1099 Y1102 K1139 R9 Q10 M13 P14 E17 Y20 K57
BS02 N6I B W1151 W1158 W1165 S1179 E1186 W69 W76 W83 S97 E104
BS03 2LO B L1109 P1110 F1111 L1120 Y1167 N1168 V1174 F1177 L27 P28 F29 L38 Y85 N86 V92 F95
Gene Ontology
Molecular Function
GO:0004402 histone acetyltransferase activity
Biological Process
GO:0006355 regulation of DNA-templated transcription

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Molecular Function
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Biological Process
External links
PDB RCSB:7ugl, PDBe:7ugl, PDBj:7ugl
PDBsum7ugl
PubMed
UniProtQ92793|CBP_HUMAN CREB-binding protein (Gene Name=CREBBP)

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