Structure of PDB 7u9k Chain B

Receptor sequence
>7u9kB (length=330) Species: 93061 (Staphylococcus aureus subsp. aureus NCTC 8325) [Search protein sequence]
ENICIVFGGKSAEHEVSILTAQNVLNAIYHVDIIYITNDGDWRKQNNITA
EIKSTDELHLEISQLLQPYDAVFPLLHGPNGEDGTIQGLFEVLDVPYVGN
GVLSAASSMDKLVMKQLFEHRGLPQLPYISFLRSEYEKYEHNILKLVNDK
LNYPVFVKPANLGSSVGISKCNNEAELKEGIKEAFQFDRKLVIEQGVNAR
EIEVAVLGNDYPEATWPGEVVKDVAFYDYKSKYKDGKVQLQIPADLDEDV
QLTLRNMALEAFKATDCSGLVRADFFVTEDNQIYINETNAMPGFTAFSMY
PKLWENMGLSYPELITKLIELAKERHQDKQ
3D structure
PDB7u9k Staphylococcus aureus D-alanine-D-alanine ligase in complex with ATP, D-ala-D-ala, Mg2+ and K+
ChainB
Resolution2.0 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 6.3.2.4: D-alanine--D-alanine ligase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide B E16 H96 S183 Y252 R291 G312 S317 E13 H77 S164 Y233 R272 G293 S298
BS02 MG B E306 N308 E287 N289
BS03 ATP B K130 F175 K177 G182 S183 S184 E213 V216 E220 F245 Y246 K251 F295 E306 K111 F156 K158 G163 S164 S165 E194 V197 E201 F226 Y227 K232 F276 E287
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0005524 ATP binding
GO:0008716 D-alanine-D-alanine ligase activity
GO:0016874 ligase activity
GO:0046872 metal ion binding
Biological Process
GO:0008360 regulation of cell shape
GO:0009252 peptidoglycan biosynthetic process
GO:0071555 cell wall organization
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7u9k, PDBe:7u9k, PDBj:7u9k
PDBsum7u9k
PubMed37948922
UniProtQ2FWH3|DDL_STAA8 D-alanine--D-alanine ligase (Gene Name=ddl)

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