Structure of PDB 7u9i Chain B

Receptor sequence
>7u9iB (length=326) Species: 9606 (Homo sapiens) [Search protein sequence]
QFYGYLSQQQNMMQDYVRTGTYQRAILQNHTDFKDKIVLDVGCGSGILSF
FAAQAGARKIYAVEASTMAQHAEVLVKSNNLTDRIVVIPGKVEEVSLPEQ
VDIIISEPMGYMLFNERMLESYLHAKKYLKPSGNMFPTIGDVHLAPFTDE
QLYMEQFTKANFWYQPSFHGVDLSALRGAAVDEYFRQPVVDTFDIRILMA
KSVKYTVNFLEAKEGDLHRIEIPFKFHMLHSGLVHGLAFWFDVAFIGSIM
TVWLSTAPTEPLTHWYQVRCLFQSPLFAKAGDTLSGTCLLIANKRQSYDI
SIVAQVDQTGSKSSNLLDLKNPFFRY
3D structure
PDB7u9i Co-crystal structure of human CARM1 in complex with MT556 inhibitor
ChainB
Resolution2.0 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.1.1.319: type I protein arginine methyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 44T B Y153 G192 E214 A215 K241 V242 E257 P258 M259 E266 M268 H414 W415 Y3 G42 E64 A65 K91 V92 E107 P108 M109 E116 M118 H264 W265
Gene Ontology
Molecular Function
GO:0016274 protein-arginine N-methyltransferase activity
Biological Process
GO:0018216 peptidyl-arginine methylation

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Molecular Function
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Biological Process
External links
PDB RCSB:7u9i, PDBe:7u9i, PDBj:7u9i
PDBsum7u9i
PubMed
UniProtQ86X55|CARM1_HUMAN Histone-arginine methyltransferase CARM1 (Gene Name=CARM1)

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