Structure of PDB 7u8y Chain B

Receptor sequence
>7u8yB (length=222) Species: 10090 (Mus musculus) [Search protein sequence]
LPHGHMQTLIFLDLEATGLPSSRPEVTELCLLAVHRRALENTSISQGHPP
PVPRPPRVVDKLSLCIAPGKACSPGASEITGLSKAELEVQGRQRFDDNLA
ILLRAFLQRQPQPCCLVAHNGDRYDFPLLQTELARLSTPSPLDGTFCVDS
IAALKALEQASRKSYSLGSIYTRLYWQAPTDSHTAEGDVLTLLSICQWKP
QALLQWVDEHARPFSTVKPMYG
3D structure
PDB7u8y TREX1 Structural Studies Capture Small Molecule Inhibition and Implicate Novel DNA Dynamics
ChainB
Resolution2.22 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.1.11.2: exodeoxyribonuclease III.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 AZN B D18 E20 G80 I84 H195 D200 D13 E15 G75 I79 H183 D188
BS02 AZN B A21 G23 L24 S78 G80 A81 Y129 A16 G18 L19 S73 G75 A76 Y124
BS03 MN B D18 E20 D200 D13 E15 D188
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0008408 3'-5' exonuclease activity

View graph for
Molecular Function
External links
PDB RCSB:7u8y, PDBe:7u8y, PDBj:7u8y
PDBsum7u8y
PubMed
UniProtQ91XB0|TREX1_MOUSE Three-prime repair exonuclease 1 (Gene Name=Trex1)

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