Structure of PDB 7u8h Chain B

Receptor sequence
>7u8hB (length=168) Species: 9606 (Homo sapiens) [Search protein sequence]
GMTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDCYRKQVVIDGE
TCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQ
IKRVKDSEDVPMVLVGNKSDLPSRTVDTKQAQDLARSYGIPFIETSAKTR
QGVDDAFYTLVREIRKHK
3D structure
PDB7u8h Fragment Optimization of Reversible Binding to the Switch II Pocket on KRAS Leads to a Potent, In Vivo Active KRAS G12C Inhibitor.
ChainB
Resolution1.702 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.6.5.2: small monomeric GTPase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 2XO B K5 V7 C39 D54 L56 Y71 T74 K6 V8 C40 D55 L57 Y72 T75
BS02 GDP B G13 V14 G15 K16 S17 A18 F28 D30 N116 K117 D119 L120 S145 A146 K147 G14 V15 G16 K17 S18 A19 F29 D31 N117 K118 D120 L121 S146 A147 K148
BS03 LX6 B E62 E63 R68 D69 M72 Q99 I100 E63 E64 R69 D70 M73 Q100 I101
Gene Ontology
Molecular Function
GO:0003924 GTPase activity
GO:0005525 GTP binding
Biological Process
GO:0007165 signal transduction
Cellular Component
GO:0016020 membrane

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Cellular Component
External links
PDB RCSB:7u8h, PDBe:7u8h, PDBj:7u8h
PDBsum7u8h
PubMed36300829
UniProtP01116|RASK_HUMAN GTPase KRas (Gene Name=KRAS)

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