Structure of PDB 7u6u Chain B

Receptor sequence
>7u6uB (length=399) Species: 9606 (Homo sapiens) [Search protein sequence]
MNNFNEEFDCHFLDEGFTAKDILDQKINEVSSSDDKDAFYVADLGDILKK
HLRWLKALPRVTPFYAVKCNDSKAIVKTLAATRTGFDCASKTEIQLVQSL
GVPPERIIYANPCKQVSQIKYAANNGVQMMTFDSEVELMKVARAHPKAKL
VLRIATDVKFGATLRTSRLLLERAKELNIDVVGVSFHVGSGCTDPETFVQ
AISDARCVFDMGAEVGFSMYLLDIGGGFPGSEDVKLKFEEITGVINPALD
KYFPSDSGVRIIAEPGRYYVASAFTLAVNIIAKKIVLEQTFMYYVNDGVY
GSFNCILYDHAHVKPLLQKRPKPDEKYYSSSIWGPTCDGLDRIVERCDLP
EMHVGDWMLFENMGAYTVAAASTFNGFQRPTIYYVMSGPAWQLMQQFQN
3D structure
PDB7u6u Structure and Enzymatic Activity of an Intellectual Disability-Associated Ornithine Decarboxylase Variant, G84R.
ChainB
Resolution1.85 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number 4.1.1.17: ornithine decarboxylase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 PLP B K69 H197 G237 E274 G276 R277 Y389 K68 H187 G227 E264 G266 R267 Y366
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0004586 ornithine decarboxylase activity
GO:0005515 protein binding
GO:0016831 carboxy-lyase activity
GO:0042803 protein homodimerization activity
Biological Process
GO:0001822 kidney development
GO:0006595 polyamine metabolic process
GO:0006596 polyamine biosynthetic process
GO:0008283 cell population proliferation
GO:0008284 positive regulation of cell population proliferation
GO:0009615 response to virus
GO:0033387 putrescine biosynthetic process from ornithine
GO:0042176 regulation of protein catabolic process
Cellular Component
GO:0005575 cellular_component
GO:0005737 cytoplasm
GO:0005829 cytosol

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:7u6u, PDBe:7u6u, PDBj:7u6u
PDBsum7u6u
PubMed36188294
UniProtP11926|DCOR_HUMAN Ornithine decarboxylase (Gene Name=ODC1)

[Back to BioLiP]