Structure of PDB 7u4n Chain B

Receptor sequence
>7u4nB (length=165) Species: 9606 (Homo sapiens) [Search protein sequence]
DDWRCARSMHEFSAKDIDGHMVNLDKYRGFVCIVTNVASQCGKTEVNYTQ
LVDLHARYAECGLRILAFPCNQFGKQEPGSNEEIKEFAAGYNVKFDMFSK
ICVNGDDAHPLWKWMKIQPKGKGILGNAIKWNFTKFLIDKNGCVVKRYGP
MEEPLVIEKDLPHYF
3D structure
PDB7u4n Small-molecule allosteric inhibitors of GPX4.
ChainB
Resolution1.6 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.11.1.12: phospholipid-hydroperoxide glutathione peroxidase.
1.11.1.9: glutathione peroxidase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 L8X B Y63 E163 P167 Y58 E158 P162
BS02 L8X B Y63 C66 Y58 C61
Gene Ontology
Molecular Function
GO:0004601 peroxidase activity
Biological Process
GO:0006979 response to oxidative stress

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Molecular Function
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Biological Process
External links
PDB RCSB:7u4n, PDBe:7u4n, PDBj:7u4n
PDBsum7u4n
PubMed36423641
UniProtP36969|GPX4_HUMAN Phospholipid hydroperoxide glutathione peroxidase GPX4 (Gene Name=GPX4)

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