Structure of PDB 7u1a Chain B

Receptor sequence
>7u1aB (length=319) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence]
TLSLQLPWVEKYRPQVLSDIVGNKETIDRLQQIAKDGNMPHMIISGMPGI
GKTTSVHCLAHELLGRSYADGVLELNASDDRGIDVVRNQIKHFAQKKLHL
PPGKHKIVILDEADSMTAGAQQALRRTMELYSNSTRFAFACNQSNKIIEP
LQSRCAILRYSKLSDEDVLKRLLQIIKLEDVKYTNDGLEAIIFTAEGDMR
QAINNLQSTVAGHGLVNADNVFKIVDSPHPLIVKKMLLASNLEDSIQILR
TDLWKKGYSSIDIVTTSFRVTKNLAQVKESVRLEMIKEIGLTHMRILEGV
GTYLQLASMLAKIHKLNNK
3D structure
PDB7u1a A second DNA binding site on RFC facilitates clamp loading at gapped or nicked DNA.
ChainB
Resolution3.3 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna B R84 I86 R90 T120 R81 I83 R87 T117
BS02 AGS B R128 R157 R125 R154
BS03 ADP B V12 R16 P17 I23 V24 G25 P51 G52 I53 G54 K55 T56 T57 M202 R203 V9 R13 P14 I20 V21 G22 P48 G49 I50 G51 K52 T53 T54 M199 R200
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003689 DNA clamp loader activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016887 ATP hydrolysis activity
Biological Process
GO:0000077 DNA damage checkpoint signaling
GO:0006260 DNA replication
GO:0006261 DNA-templated DNA replication
GO:0006271 DNA strand elongation involved in DNA replication
GO:0006272 leading strand elongation
GO:0006281 DNA repair
GO:0007062 sister chromatid cohesion
GO:0007064 mitotic sister chromatid cohesion
GO:0090618 DNA clamp unloading
Cellular Component
GO:0005634 nucleus
GO:0005663 DNA replication factor C complex
GO:0005829 cytosol
GO:0031389 Rad17 RFC-like complex
GO:0031390 Ctf18 RFC-like complex
GO:0031391 Elg1 RFC-like complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7u1a, PDBe:7u1a, PDBj:7u1a
PDBsum7u1a
PubMed35731107
UniProtP40339|RFC4_YEAST Replication factor C subunit 4 (Gene Name=RFC4)

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