Structure of PDB 7u0s Chain B

Receptor sequence
>7u0sB (length=114) Species: 330879 (Aspergillus fumigatus Af293) [Search protein sequence]
GSSGVTKELKSPGNGVDFPKKGDFVTIHYTGRLTDGSKFDSSVDRNEPFQ
TQIGTGRVIKGWDEGVPQMSLGEKAVLTITPDYGYGARGFPGVIPGNSTL
IFEVELLGINNKRA
3D structure
PDB7u0s Structure-Guided Synthesis of FK506 and FK520 Analogs with Increased Selectivity Exhibit In Vivo Therapeutic Efficacy against Cryptococcus.
ChainB
Resolution1.7 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 5.2.1.8: peptidylprolyl isomerase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 KXX B F117 P118 F90 P91
BS02 KXX B Y56 F66 D67 F76 V85 W89 Y112 F117 F129 Y29 F39 D40 F49 V58 W62 Y85 F90 F102
Gene Ontology
Molecular Function
GO:0003755 peptidyl-prolyl cis-trans isomerase activity
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol

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Molecular Function
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Cellular Component
External links
PDB RCSB:7u0s, PDBe:7u0s, PDBj:7u0s
PDBsum7u0s
PubMed35604094
UniProtQ4WLV6|FKB1A_ASPFU FK506-binding protein 1A (Gene Name=fpr1A)

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