Structure of PDB 7tts Chain B

Receptor sequence
>7ttsB (length=440) Species: 9606 (Homo sapiens) [Search protein sequence]
SNKDAALLEAARANNMQEVSRLLSEGADVNAKHRLGWTALMVAAINRNNS
VVQVLLAAGADPNLGSFKGCTALHYAVLADDYRTVKELLDGGANPLQRNE
MGHTPLDYAREGEVMKLLRTSEAKYQEKQRKREAEERRRFPLEQRLKEHI
IGQESAIATVGAAIRRKENGWYDEEHPLVFLFLGSSGIGKTELAKQTAKY
MHKDAKKGFIRLDMSEFQERHEVAKFIGSPPGYVGHEEGGQLTKKLKQCP
NAVVLFDEVDKAHPDVLTIMLQLFDEGRLTDGKGKTIDCKDAIFIMTSNV
ASDEIAQHALQLRQEALETISKNFKENVIRPILKAHFRRDEFLGRINEIV
YFLPFCHSELIQLVNKELNFWAKRAKQRHNITLLWDREVADVLVDGYNVH
YGARSIKHEVERRVVNQLAAAYEQDLLPGGCTLRITVEDS
3D structure
PDB7tts Unique structural features govern the activity of a human mitochondrial AAA+ disaggregase, Skd3.
ChainB
Resolution2.9 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.6.1.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide B G429 Y430 V431 G232 Y233 V234
BS02 AGS B I348 S383 G384 I385 G386 K387 T388 E389 F571 L579 A619 R620 I151 S186 G187 I188 G189 K190 T191 E192 F355 L363 A403 R404
BS03 AGS B E557 R561 E341 R345
Gene Ontology
Molecular Function
GO:0005524 ATP binding
GO:0016887 ATP hydrolysis activity

View graph for
Molecular Function
External links
PDB RCSB:7tts, PDBe:7tts, PDBj:7tts
PDBsum7tts
PubMed36170828
UniProtQ9H078|CLPB_HUMAN Mitochondrial disaggregase (Gene Name=CLPB)

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