Structure of PDB 7tpt Chain B

Receptor sequence
>7tptB (length=385) Species: 9913 (Bos taurus) [Search protein sequence]
QGRKVVVCDNGTGFVKCGYAGSNFPEHIFPALVGRPIIRSTTKVGNIEIK
DLMVGDEASELRSMLEVNYPMENGIVRNWDDMKHLWDYTFGPEKLNIDTR
NCKILLTEPPMNPTKNREKIVEVMFETYQFSGVYVAIQAVLTLYAQGLLT
GVVVDSGDGVTHICPVYEGFSLPHLTRRLDIAGRDITRYLIKLLLLRGYA
FNHSADFETVRMIKEKLCYVGYNIEQEQKLALETTVLVESYTLPDGRIIK
VGGERFEAPEALFQPHLINVEGVGVAELLFNTIQAADIDTRSEFYKHIVL
SGGSTMYPGLPSRLERELKQLYLERVLKGDVEKLSKFKIRIEDPPRRKHM
VFLGGAVLADIMKDKDNFWMTRQEYQEKGVRVLEK
3D structure
PDB7tpt Structure of Arp2/3 complex at a branched actin filament junction resolved by single-particle cryo-electron microscopy.
ChainB
Resolution3.9 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide B E75 I78 R80 P116 R181 E72 I75 R77 P113 R178
BS02 ADP B D161 R214 K217 G306 S307 Y310 D158 R211 K214 G303 S304 Y307
Gene Ontology
Molecular Function
GO:0003779 actin binding
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0051015 actin filament binding
Biological Process
GO:0010592 positive regulation of lamellipodium assembly
GO:0034314 Arp2/3 complex-mediated actin nucleation
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:1905168 positive regulation of double-strand break repair via homologous recombination
GO:2001032 regulation of double-strand break repair via nonhomologous end joining
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005856 cytoskeleton
GO:0005885 Arp2/3 protein complex
GO:0005938 cell cortex
GO:0035861 site of double-strand break
GO:0042995 cell projection

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7tpt, PDBe:7tpt, PDBj:7tpt
PDBsum7tpt
PubMed35622886
UniProtA7MB62|ARP2_BOVIN Actin-related protein 2 (Gene Name=ACTR2)

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