Structure of PDB 7thv Chain B

Receptor sequence
>7thvB (length=314) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence]
QLPWVEKYRPQVLSDIVGNKETIDRLQQIAKDGNMPHMIISGMPGIGKTT
SVHCLAHELLGRSYADGVLELNASDDRGIDVVRNQIKHFAQKKLHLPPGK
HKIVILDEADSMTAGAQQALRRTMELYSNSTRFAFACNQSNKIIEPLQSR
CAILRYSKLSDEDVLKRLLQIIKLEDVKYTNDGLEAIIFTAEGDMRQAIN
NLQSTVAGHGLVNADNVFKIVDSPHPLIVKKMLLASNLEDSIQILRTDLW
KKGYSSIDIVTTSFRVTKNLAQVKESVRLEMIKEIGLTHMRILEGVGTYL
QLASMLAKIHKLNN
3D structure
PDB7thv Cryo-EM structures reveal high-resolution mechanism of a DNA polymerase sliding clamp loader.
ChainB
Resolution4.0 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 AGS B V12 P17 V24 G54 K55 T56 T57 N145 M202 R203 V5 P10 V17 G47 K48 T49 T50 N138 M195 R196
BS02 MG B T56 D114 T49 D107
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003689 DNA clamp loader activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016887 ATP hydrolysis activity
Biological Process
GO:0000077 DNA damage checkpoint signaling
GO:0006260 DNA replication
GO:0006261 DNA-templated DNA replication
GO:0006271 DNA strand elongation involved in DNA replication
GO:0006272 leading strand elongation
GO:0006281 DNA repair
GO:0007062 sister chromatid cohesion
GO:0007064 mitotic sister chromatid cohesion
GO:0090618 DNA clamp unloading
Cellular Component
GO:0005634 nucleus
GO:0005663 DNA replication factor C complex
GO:0005829 cytosol
GO:0031389 Rad17 RFC-like complex
GO:0031390 Ctf18 RFC-like complex
GO:0031391 Elg1 RFC-like complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7thv, PDBe:7thv, PDBj:7thv
PDBsum7thv
PubMed35179493
UniProtP40339|RFC4_YEAST Replication factor C subunit 4 (Gene Name=RFC4)

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