Structure of PDB 7ths Chain B

Receptor sequence
>7thsB (length=247) Species: 9606 (Homo sapiens) [Search protein sequence]
AAPSFDCGKPQVEPKKCPGRVVGGCVAHPHSWPWQVSLRTRFGMHFCGGT
LISPEWVLTAAHCLEKSPRPSSYKVILGAHQEVPHVQEIEVSRLFLEPTR
KDIALLKLSSPAVITDKVIPACLPSPNYVVADRTECFITGWGETQGTFGA
GLLKEAQLPVIENKVCNRYEFLNGRVQSTELCAGHLAGGTDSCQGDAGGP
LVCFEKDKYILQGVTSWGLGCARPNKPGVYVRVSRFVTWIEGVMRNN
3D structure
PDB7ths Synthesis and Structural Characterization of Macrocyclic Plasmin Inhibitors.
ChainB
Resolution1.8 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.4.21.7: plasmin.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 I5Y B F583 M585 F42 M44
BS02 I5Y B H603 R719 D735 S736 C737 Q738 S760 W761 G762 G764 C765 H62 R175 D191 S192 C193 Q194 S216 W217 G218 G220 C221
BS03 I5Q B Y713 E714 F715 N717 R719 K770 Y169 E170 F171 N173 R175 K226
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:7ths, PDBe:7ths, PDBj:7ths
PDBsum7ths
PubMed36710259
UniProtP00747|PLMN_HUMAN Plasminogen (Gene Name=PLG)

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