Structure of PDB 7tbe Chain B

Receptor sequence
>7tbeB (length=357) Species: 5855 (Plasmodium vivax) [Search protein sequence]
VKNAHAVVEQTEENVFLIPLKHLRDSQFVGTLLVGVPPQEIHPIFDTGST
NLWVVTTDCEEESCKKVKRYNPYKSKTFRRSFIGKNLHIVFGSGSISGSI
GKETFVLGDHTVRNQTFGLVESESNNIFDYIDFEGIVGLGFPEMLSAGKV
SFFDNLLSQNKNLSPQFSFYISPEDNTSTFLVGGVSKSFYEGSIYMLPVV
KEYYWEVELDGIYVGEKKICCEEKSYAIFDTGTSYNTMPSAQMKGFFDVV
PSAPCTEENYQEVLKNYPVIKYLFGDLVIELLPEEYMILNEESCIPAYMQ
IDVPSEKNHAYLLGSIAFMRHYYTVFVRGAGGQPSMVGVAKARAAAEAAQ
KVAELEN
3D structure
PDB7tbe Basis for drug selectivity of plasmepsin IX and X inhibition in Plasmodium falciparum and vivax.
ChainB
Resolution3.35 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.4.23.1: pepsin A.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 I0I B I229 D231 F276 I322 F324 Y395 D421 G423 T424 I492 L503 I44 D46 F91 I131 F133 Y204 D230 G232 T233 I301 L312
Gene Ontology
Molecular Function
GO:0004190 aspartic-type endopeptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:7tbe, PDBe:7tbe, PDBj:7tbe
PDBsum7tbe
PubMed35460613
UniProtA5KAC3

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