Structure of PDB 7tb1 Chain B

Receptor sequence
>7tb1B (length=126) Species: 9606 (Homo sapiens) [Search protein sequence]
SAQELKEQGNRLFVGRKYPEAAACYGRAITRNPLVAVYYTNRALCYLKMQ
QHEQALADCRRALELDGQSVKAHFFLGQCQLEMESYDEAIANLQRAYSLA
KEQRLNFGDDIPSALRIAKKKRWNSI
3D structure
PDB7tb1 Discovery and Structure-Based Design of Macrocyclic Peptides Targeting STUB1.
ChainB
Resolution1.785 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.3.2.27: RING-type E3 ubiquitin transferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide B N34 F37 Y49 V61 N65 L68 K95 F98 Q102 F131 D134 I135 N10 F13 Y25 V37 N41 L44 K71 F74 Q78 F107 D110 I111
BS02 I1J B F37 V38 F13 V14
External links
PDB RCSB:7tb1, PDBe:7tb1, PDBj:7tb1
PDBsum7tb1
PubMed35853179
UniProtQ9UNE7|CHIP_HUMAN E3 ubiquitin-protein ligase CHIP (Gene Name=STUB1)

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