Structure of PDB 7t3y Chain B

Receptor sequence
>7t3yB (length=304) Species: 1263720 (Betacoronavirus England 1) [Search protein sequence]
HHHSGLVKMSHPSGDVEACMVQVTCGSMTLNGLWLDNTVWCPRHVMCPAD
QLSDPNYDALLISMTNHSFSVQKHIANLRVVGHAMQGTLLKLTVDVANPS
TPAYTFTTVKPGAAFSVLACYNGRPTGTFTVVMRPNYTIKGSFLCGSCGS
VGYTKEGSVINFCYMHQMELANGTHTGSAFDGTMYGAFMDKQVHQVQLTD
KYCSVNVVAWLYAAILNGCAWFVKPNRTSVVSFNEWALANQFTEFVGTQS
VDMLAVKTGVAIEQLLYAIQQLYTGFQGKQILGSTMLEDEFTPEDVNMQI
MGVV
3D structure
PDB7t3y Structure-Guided Design of Potent Spirocyclic Inhibitors of Severe Acute Respiratory Syndrome Coronavirus-2 3C-like Protease.
ChainB
Resolution1.9 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.7.50: mRNA guanylyltransferase.
3.4.19.12: ubiquitinyl hydrolase 1.
3.4.22.-
3.4.22.69: SARS coronavirus main proteinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 F5L B H41 F143 C148 H166 Q167 M168 E169 D190 Q192 H44 F143 C148 H166 Q167 M168 E169 D190 Q192
BS02 F8C B F143 L144 G146 S147 C148 H166 Q167 E169 D190 Q192 F143 L144 G146 S147 C148 H166 Q167 E169 D190 Q192
Gene Ontology
Molecular Function
GO:0008233 peptidase activity
Biological Process
GO:0019082 viral protein processing

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Molecular Function
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Biological Process
External links
PDB RCSB:7t3y, PDBe:7t3y, PDBj:7t3y
PDBsum7t3y
PubMed35638577
UniProtK9N638|R1A_MERS1 Replicase polyprotein 1a (Gene Name=1a)

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