Structure of PDB 7t1g Chain B

Receptor sequence
>7t1gB (length=313) Species: 559292 (Saccharomyces cerevisiae S288C) [Search protein sequence]
RITQEISYNCDYGDNTFNLAIDIGGTLAKVVFSPIHSNRLMFYTIKFMEL
LHSIIKEHNNGCYRMTHIIATGGGAFKFYDLLYENFPQIKGISRFEEMEG
LIHGLDFFIHEIPDEVFTYNDQDGERIIPTSSIYPYLLVNIGSGVSILKV
TEPNNFSRVGGSSLGGGTLWGLLSLITGAQTYDQMLDWAQEGDNSSVDML
VGDIYSAIASSFGKVFQLYSSHESIEGQMFKNPDICKSLLFAISNNIGQI
AYLQAKINNIQNIYFGGSYTRGHLTTMNTLSYAINFWSQGSKQAFFLKHE
GYLGAMGAFLSAS
3D structure
PDB7t1g High-resolution crystal structure and chemical screening reveal pantothenate kinase as a new target for antifungal development.
ChainB
Resolution2.0 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.1.33: pantothenate kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 E66 B E105 V160 R173 G176 S177 E97 V145 R158 G161 S162
Gene Ontology
Molecular Function
GO:0004594 pantothenate kinase activity
GO:0005524 ATP binding
GO:0016301 kinase activity
Biological Process
GO:0008204 ergosterol metabolic process
GO:0015937 coenzyme A biosynthetic process
GO:0016310 phosphorylation
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7t1g, PDBe:7t1g, PDBj:7t1g
PDBsum7t1g
PubMed36167065
UniProtQ04430|PANK_YEAST Pantothenate kinase CAB1 (Gene Name=CAB1)

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