Structure of PDB 7sz8 Chain B

Receptor sequence

>7sz8B (length=416) Species: 9606 (Homo sapiens)

DVNDNEPIFVSSPFQATVLENVPLGYPVVHIQAVDADSGENARLHYRLVD
FPFQIHNSSGWITVCAELDREEVEHYSFGVEAVDHGSPPMSSSTSVSITV
LDVNDNDPVFTQPTYELRLNEDAAVGSSVLTLQARDRDANSVITYQLTGG
NTRNRFALSSQRGGGLITLALPLDYKQEQQYVLAVTASDGTRSHTAHVLI
NVTDANTHRPVFQSSHYTVSVSEDRPVGTSIATLSANDEDTGENARITYV
IQDPVPQFRIDPDSGTMYTMMELDYENQVAYTLTIMAQDNGIPQKSDTTT
LEILILDANDNAPQFLWDFYQGSIFEDAPPSTSILQVSATDRDSGPNGRL
LYTFQGGDDGDGDFYIEPTSGVIRTQRRLDRENVAVYNLWALAVDRGSPT
PLSASVEIQVTILDIN

3D structure

• PDB: 7sz8 Crystal structure of human CELSR1 EC4-7
• Chain: B
• Resolution: 2.337 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	CA	B	N324 N326 D356 D358 N362 D426	N3 N5 D35 D37 N41 D84
BS02	CA	B	E341 E413 D444 V445 D447 D480	E20 E71 D102 V103 D105 D138
BS03	CA	B	E341 D411 E413 D447	E20 D69 E71 D105
BS04	CA	B	N446 N448 D478 D480 D531	N104 N106 D136 D138 D189
BS05	CA	B	N548 H550 D580 D582 N586 D631	N206 H208 D238 D240 N244 D289
BS06	CA	B	E565 E618 D649 A650 D652 D685	E223 E276 D307 A308 D310 D343
BS07	CA	B	E565 D616 E618 D652	E223 D274 E276 D310
BS08	CA	B	N651 N653 D683 D685 N689 D737	N309 N311 D341 D343 N347 D395

Gene Ontology

Molecular Function

• GO:0005509 calcium ion binding

Biological Process

• GO:0007155 cell adhesion
• GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules
• GO:0098609 cell-cell adhesion

Cellular Component

• GO:0005886 plasma membrane
• GO:0016020 membrane

External links

• PDB: RCSB:7sz8, PDBe:7sz8, PDBj:7sz8
• PDBsum: 7sz8
• UniProt: Q9NYQ6|CELR1_HUMAN Cadherin EGF LAG seven-pass G-type receptor 1 (Gene Name=CELSR1)