Structure of PDB 7sqa Chain B

Receptor sequence
>7sqaB (length=256) Species: 9606 (Homo sapiens) [Search protein sequence]
MQLNPESADLRALAKHLYDSYIKSFPLTKAKARAILTGKTTDKSPFVIYD
MNSLMMGEDKIKFKHITQSKEVAIRIFQGCQFRSVEAVQEITEYAKSIPG
FVNLDLNDQVTLLKYGVHEIIYTMLASLMNKDGVLISEGQGFMTREFLKS
LRKPFGDFMEPKFEFAVKFNALELDDSDLAIFIAVIILSGDRPGLLNVKP
IEDIQDNLLQALELQLKLNHPESSQLFAKLLQKMTDLRQIVTEHVQLLQV
IKKTET
3D structure
PDB7sqa PPAR gamma Corepression Involves Alternate Ligand Conformation and Inflation of H12 Ensembles.
ChainB
Resolution2.499 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide B V293 T297 K301 V315 L318 K319 V88 T92 K96 V110 L113 K114
BS02 A8R B G284 C285 R288 S289 H323 I326 L330 I341 S342 M364 G79 C80 R83 S84 H118 I121 L125 I136 S137 M159
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0004879 nuclear receptor activity
Biological Process
GO:0006355 regulation of DNA-templated transcription
Cellular Component
GO:0005634 nucleus

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7sqa, PDBe:7sqa, PDBj:7sqa
PDBsum7sqa
PubMed37146157
UniProtP37231|PPARG_HUMAN Peroxisome proliferator-activated receptor gamma (Gene Name=PPARG)

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