Structure of PDB 7sp0 Chain B

Receptor sequence
>7sp0B (length=244) Species: 9606 (Homo sapiens) [Search protein sequence]
EKTYTQRCRLFVGNLPADITEDEFKRLFAKYGEPGEVFINKGKGFGFIKL
ESRALAEIAKAELDDTPMRGRQLRVRFATAALSVRNLSPYVSNELLEEAF
SQFGPIERAVVIVDDRGRSTGKGIVEFASKPAARKAFERCSEGVFLLTTT
PRPVIVEPLEQLDDEDGLPEKLAQKNPMYQKERETPPRFAQHGTFEYEYS
QRWKSLDEMEKQQREQVEKNMKDAKDKLESEMEDAYHEHQANIL
3D structure
PDB7sp0 Familial ALS-associated SFPQ variants promote the formation of SFPQ cytoplasmic aggregates in primary neurons.
ChainB
Resolution1.83 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN B H483 E489 H192 E198
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0003723 RNA binding

View graph for
Molecular Function
External links
PDB RCSB:7sp0, PDBe:7sp0, PDBj:7sp0
PDBsum7sp0
PubMed36168806
UniProtP23246|SFPQ_HUMAN Splicing factor, proline- and glutamine-rich (Gene Name=SFPQ)

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