Structure of PDB 7sl6 Chain B

Receptor sequence
>7sl6B (length=819) Species: 10090 (Mus musculus) [Search protein sequence]
HLYPGEVCPGMDIRNNLTRLHELENCSVIEGHLQILLMFKTRPEDFRDLS
FPKLIMITDYLLLFRVYGLESLKDLFPNLTVIRGSRLFFNYALVIFEMVH
LKELGLYNLMNITRGSVRIEKNNELCYLATIDWSRILDSVEDNYIVLNKD
DNEECGDVCPGTNCPATVINGQFVERCWTHSHCQKVCPTICKSHGCTAEG
LCCHKECLGNCSEPDDPTKCVACRNFYLDGQCVETCPPPYYHFQDWRCVN
FSFCQDLHFKCRNSRCHQYVIHNNKCIPECPSGYTMNSSNLMCTPCLGPC
PKVCQILEGEKTIDSVTSAQELRGCTVINGSLIINIRGGNNLAAELEANL
GLIEEISGFLKIRRSYALVSLSFFRKLHLIRGETLEIGNYSFYALDNQNL
RQLWDWSKHNLTITQGKLFFHYNPKLCLSEIHKMEEVSGTKGRQERNDIA
LKTNGDQASCENELLKFSFIRTSFDKILLRWEPYWPPDFRDLLGFMLFYK
EAPYQNVTEFSWTVVDIDPPQRSHPGWLMRGLKPWTQYAIFVKTLVTFSD
ERRTYGAKSDIIYVQTDATNPSVPLDPISVSNSSSQIILKWKPPSDPNGN
ITHYLVYWERQAEDSELFELDYCLKGLKLPSRCPKTDSQILKELEESSFR
KTFEDYLHNVVFVPRPHRPFEKVVNKESLVISGLRHFTGYRIELQACNQD
SPDERCSVAAYVSARTMPEAKADDIVGPVTHEIFENNVVHLMWQEPKEPN
GLIVLYEVSYRRYGDEELHLCVSRKHFALERGCRLRGLSPGNYSVRVRAT
SLAGNGSWTEPTYFYVTDY
3D structure
PDB7sl6 Synergistic activation of the insulin receptor via two distinct sites.
ChainB
Resolution3.7 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.10.1: receptor protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide B P495 D496 F497 R498 R539 H712 V717 R719 P487 D488 F489 R490 R522 H658 V663 R665
BS02 peptide B R14 N15 L37 F39 K40 R65 R14 N15 L37 F39 K40 R65
BS03 peptide B D496 N713 V717 P718 R719 D488 N659 V663 P664 R665
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0005524 ATP binding
GO:0043548 phosphatidylinositol 3-kinase binding
GO:0043560 insulin receptor substrate binding
Biological Process
GO:0006468 protein phosphorylation
GO:0007169 cell surface receptor protein tyrosine kinase signaling pathway
GO:0046777 protein autophosphorylation
Cellular Component
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7sl6, PDBe:7sl6, PDBj:7sl6
PDBsum7sl6
PubMed35361965
UniProtP15208|INSR_MOUSE Insulin receptor (Gene Name=Insr)

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