Structure of PDB 7sl1 Chain B

Receptor sequence
>7sl1B (length=813) Species: 10090 (Mus musculus) [Search protein sequence]
HLYPGEVCPGMDIRNNLTRLHELENCSVIEGHLQILLMFKTRPEDFRDLS
FPKLIMITDYLLLFRVYGLESLKDLFPNLTVIRGSRLFFNYALVIFEMVH
LKELGLYNLMNITRGSVRIEKNNELCYLATIDWSRILDSVEDNYIVLNKD
DNEECGDVCPGTAKGKTNCPATVQFVERCWTHSHCQKVCPTICKSHGCTA
EGLCCHKECLGNCSEPDDPTKCVACRNFYLDGQCVETCPPPYYHFQDWRC
VNFSFCQDLHFKCRNSRKPGCHQYVIHNNKCIPECPSGYTMNSSNLMCTP
CLGPCPKVCQILEGEKTIDSVTSAQELRGCTVINGSLIINIRGGNNLAAE
LEANLGLIEEISGFLKIRRSYALVSLSFFRKLHLIRGETLEIGNYSFYAL
DNQNLRQLWDWSKHNLTITQGKLFFHYNPKLCLSEIHKMEEVSGTKGRQE
RNDIALKTNGDQASCENELLKFSFIRTSFDKILLRWEPYWPPDFRDLLGF
MLFYKEAPYQNVTEFSWTVVDIDPPQRSHPGWLMRGLKPWTQYAIFVKTL
VTFSDERRTYGAKSDIIYVQTDATNPSVPLDPISVSNSSSQIILKWKPPS
DPNGNITHYLVYWERQAEDSELFELDYCLKGLKLPSRTDSQILKELEESS
FRKTFEDYLHNHRPFEKVVNKESLVISGLRHFTGYRIELQACNQDSPDER
CSVAAYVSARTMPEAKADDIVGPVTHEIFENNVVHLMWQEPKEPNGLIVL
YEVSYRRYGDEELHLCVSRKHFALERGCRLRGLSPGNYSVRVRATSLAGN
GSWTEPTYFYVTD
3D structure
PDB7sl1 Synergistic activation of the insulin receptor via two distinct sites.
ChainB
Resolution3.4 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.10.1: receptor protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide B R479 K484 L486 L554 R556 R476 K481 L483 L533 R535
BS02 peptide B L315 E316 L312 E313
BS03 peptide B R488 D535 P537 P551 G552 W553 R556 R485 D523 P525 P530 G531 W532 R535
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0005524 ATP binding
GO:0043548 phosphatidylinositol 3-kinase binding
GO:0043560 insulin receptor substrate binding
Biological Process
GO:0006468 protein phosphorylation
GO:0007169 cell surface receptor protein tyrosine kinase signaling pathway
GO:0046777 protein autophosphorylation
Cellular Component
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7sl1, PDBe:7sl1, PDBj:7sl1
PDBsum7sl1
PubMed35361965
UniProtP15208|INSR_MOUSE Insulin receptor (Gene Name=Insr)

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