Structure of PDB 7siu Chain B

Receptor sequence
>7siuB (length=284) Species: 9606 (Homo sapiens) [Search protein sequence]
NLYFQHYDLLQRLGGGTYGEVFKARDKVSGDLVALKMVKMEPDDDVSTLQ
KEILILKTCRHANIVAYHGSYLWLQKLWICMEFCGAGSLQDIYQVTGSLS
ELQISYVCREVLQGLAYLHSQKKIHRDIKGANILINDAGEVRLADFGISA
QIGATLARRLSFIGTPYWMAPEVAAVALKGGYNELCDIWSLGITAIELAE
LQPPLFDVHPLRVLFLMTKSGYQPPRLKEKGKWSAAFHNFIKVTLTASPA
ARPSATKMLSHQLVSQPGLNRGLILDLLDKLKNP
3D structure
PDB7siu The HPK1 Inhibitor A-745 Verifies the Potential of Modulating T Cell Kinase Signaling for Immunotherapy.
ChainB
Resolution1.786 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 9ID B L23 A44 K46 M91 C94 G97 L144 A154 D155 F156 L13 A34 K36 M81 C84 G87 L134 A144 D145 F146
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:7siu, PDBe:7siu, PDBj:7siu
PDBsum7siu
PubMed35188729
UniProtQ92918|M4K1_HUMAN Mitogen-activated protein kinase kinase kinase kinase 1 (Gene Name=MAP4K1)

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