Structure of PDB 7shn Chain B

Receptor sequence
>7shnB (length=607) Species: 9606 (Homo sapiens) [Search protein sequence]
MNRVFLQRLLWLLRLLFPRVLCRETGLLALHSAALVSRTFLSVYVARLDG
RLARCIVRKDPRAFGWQLLQWLLIALPATFVNSAIRYLEGQLALSFRSRL
VAHAYRLYFSQQTYYRVSNMDGRLRNPDQSLTEDVVAFAASVAHLYSNLT
KPLLDVAVTSYTLLRAARSRGAGTAWPSAIAGLVVFLTANVLRAFSPKFG
ELVAEEARRKGELRYMHSRVVANSEEIAFYGGHEVELALLQRSYQDLASQ
INLILLERLWYVMLEQFLMKYVWSASGLLMVAVPIITATGKKAALEKKEE
ELVSERTEAFTIARNLLTAAADAIERIMSSYKEVTELAGYTARVHEMFQV
FEDVQRCHFKRKIRGQVVDVEQGIICENIPIVTPSGEVVVASLNIRVEEG
MHLLITGPNGCGKSSLFRILGGLWPTYGGVLYKPPPQRMFYIPQRPYMSV
GSLRDQVIYPDSVEDMQRKGYSEQDLEAILDVVHLHHILQREGGWEAMCD
WKDVLSGGEKQRIGMARMFYHRPKYALLDQCTSAVSIDVEGKIFQAAKDA
GIALLSITHRPSLWKYHTHLLQFDGEGGWKFEKLDSAAAAAAAAAAAAAA
AAAAAAA
3D structure
PDB7shn Structural basis of acyl-CoA transport across the peroxisomal membrane by human ABCD1.
ChainB
Resolution3.1 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.1.2.-
7.6.2.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 3VV B L229 A232 M335 W339 M346 P350 E380 A388 R389 L392 A396 L163 A166 M269 W273 M280 P284 E305 A313 R314 L317 A321
Gene Ontology
Molecular Function
GO:0005324 long-chain fatty acid transmembrane transporter activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0015607 ABC-type fatty-acyl-CoA transporter activity
GO:0016787 hydrolase activity
GO:0016887 ATP hydrolysis activity
GO:0019899 enzyme binding
GO:0042626 ATPase-coupled transmembrane transporter activity
GO:0042802 identical protein binding
GO:0042803 protein homodimerization activity
GO:0043531 ADP binding
GO:0046982 protein heterodimerization activity
GO:0047617 fatty acyl-CoA hydrolase activity
GO:0052817 very long-chain fatty acyl-CoA hydrolase activity
GO:0140359 ABC-type transporter activity
Biological Process
GO:0000038 very long-chain fatty acid metabolic process
GO:0002082 regulation of oxidative phosphorylation
GO:0006635 fatty acid beta-oxidation
GO:0007031 peroxisome organization
GO:0015910 long-chain fatty acid import into peroxisome
GO:0015916 fatty-acyl-CoA transport
GO:0015919 peroxisomal membrane transport
GO:0030497 fatty acid elongation
GO:0031998 regulation of fatty acid beta-oxidation
GO:0032000 positive regulation of fatty acid beta-oxidation
GO:0036109 alpha-linolenic acid metabolic process
GO:0036113 very long-chain fatty-acyl-CoA catabolic process
GO:0042758 long-chain fatty acid catabolic process
GO:0042760 very long-chain fatty acid catabolic process
GO:0043217 myelin maintenance
GO:0043651 linoleic acid metabolic process
GO:0051900 regulation of mitochondrial depolarization
GO:0055085 transmembrane transport
GO:0055089 fatty acid homeostasis
GO:0055092 sterol homeostasis
GO:1900016 negative regulation of cytokine production involved in inflammatory response
GO:1900407 regulation of cellular response to oxidative stress
GO:1903427 negative regulation of reactive oxygen species biosynthetic process
GO:1990535 neuron projection maintenance
GO:2001280 positive regulation of unsaturated fatty acid biosynthetic process
Cellular Component
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005764 lysosome
GO:0005765 lysosomal membrane
GO:0005777 peroxisome
GO:0005778 peroxisomal membrane
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0005829 cytosol
GO:0016020 membrane
GO:0031966 mitochondrial membrane
GO:0048471 perinuclear region of cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7shn, PDBe:7shn, PDBj:7shn
PDBsum7shn
PubMed34754073
UniProtP33897|ABCD1_HUMAN ATP-binding cassette sub-family D member 1 (Gene Name=ABCD1)

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