Structure of PDB 7sh1 Chain B

Receptor sequence

>7sh1B (length=626) Species: 324833 (Streptomyces lasalocidi)

CAADSHDMIRVHGARENNLKNVQVEIPKRRLTVFTGVSGSGKSSLVFDTI
AAESQRLINETYSARPEVDVLDGLTTAILVDQQPMGTSLRSTVGTATDAG
TLLRILFSRLAKPYIGTQKAFAFNVASGGMCLACEGIGSCSECHGTRLSE
TARSAKIDGLSIADASAMQISDLAAWIRGLTDPSVTTLLTVLGQTLESFV
QIGLGYLSLDRSSSTLSGGEAQRVKMVRHLGSALTDVTYVFDEPTVGLHP
HDIQRMNELLLRLRDKGNTVLVVEHKPETIVIADHVVDLGPLAGTKGGEV
VFEGTVEGLRASGTVTGRHLDDRASLKPSVRQRTGVVEVRGADAHNLRDV
DVDIPLGVLTVVTGVAGSGKSSLIHGSVAGRDGVVTVDQSPIKGSRRSNP
ATYTGMLEPIRKTFAKANGVKPALFSPNSEGACPTCKGAGVVATTCEDCG
GKRFQPSVLQYRVGGRDISEVFAMPVAEAAEFFRTGEARTPAACTVLDRL
AEVGLGYLSLGQPLTTLSGGERQRLKLAGHMGGAGSVYILDEPTSGLHLA
DVEQLLRLLDRLVDSGKTVIVVEHHQAVMAHADWIIDLGPGAGHDGGRVV
FEGTPADLVAARSTLTGEHLAQYVGA

3D structure

• PDB: 7sh1 Structural and functional analyses of the echinomycin resistance conferring protein Ecm16 from Streptomyces lasalocidi.
• Chain: B
• Resolution: 2.04 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	ADP	B	N31 N32 G53 S54 G55 K56 S57 S58 Y673 Q678 T682	N17 N18 G39 S40 G41 K42 S43 S44 Y507 Q512 T516
BS02	ADP	B	Y362 R367 H501 N502 G523 S524 G525 K526 S527 S528	Y206 R211 H345 N346 G367 S368 G369 K370 S371 S372
BS03	ZN	B	C589 C592 C612 C615	C433 C436 C446 C449
BS04	ZN	B	C176 C179 C296 C299	C131 C134 C140 C143

Gene Ontology

Molecular Function

• GO:0003677 DNA binding
• GO:0005524 ATP binding
• GO:0016887 ATP hydrolysis activity
• GO:0046872 metal ion binding

Cellular Component

• GO:0005737 cytoplasm

External links

• PDB: RCSB:7sh1, PDBe:7sh1, PDBj:7sh1
• PDBsum: 7sh1
• PubMed: 37198233
• UniProt: Q0X0A9