Structure of PDB 7seo Chain B

Receptor sequence
>7seoB (length=93) Species: 9606 (Homo sapiens) [Search protein sequence]
KIPVEADFLYAYSTAPGYYSWRNSKDGSWFIQSLCAMLKQYADKLEFMHI
LTRVNRKVATEFESFSFDATFHAKKQIPCIVSMLTKELYFYHH
3D structure
PDB7seo Structure-Based Design and Biological Evaluation of Novel Caspase-2 Inhibitors Based on the Peptide AcVDVAD-CHO and the Caspase-2-Mediated Tau Cleavage Sequence YKPVD314.
ChainB
Resolution3.25 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.4.22.56: caspase-3.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide B Y204 S205 W206 R207 N208 S209 W214 F250 F252 F256 Y19 S20 W21 R22 N23 S24 W29 F65 F67 F71
Gene Ontology
Molecular Function
GO:0004197 cysteine-type endopeptidase activity
GO:0008234 cysteine-type peptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:7seo, PDBe:7seo, PDBj:7seo
PDBsum7seo
PubMed35059567
UniProtP42574|CASP3_HUMAN Caspase-3 (Gene Name=CASP3)

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