Structure of PDB 7sck Chain B

Receptor sequence
>7sckB (length=598) Species: 9606 (Homo sapiens) [Search protein sequence]
DLSCRMHTCFDVYRCGFNPKNKIKVYIYAISREYNELLMAISDSDYYTDD
INRACLFVPSIDVLNQNTLRIKETAQAMAQLSRWDRGTNHLLFNMLPGGP
PDYNTALDVPRDRALLAGGGFSTWTYRQGYDVSIPVYSPLSAEVDLPEKG
PGPRQYFLLSSQVGLHPEYREDLEALQVKHGESVLVLDKRKRCHKHQVFD
YPQVLQEATFCVVLRGARLGQAVLSDVLQAGCVPVVIADSYILPFSEVLD
WKRASVVVPEEKMSDVYSILQSIPQRQIEEMQRQARWFWEAYFQSIKAIA
LATLQIINDRIYPYAAISYEEWNDPPAVKWGSVSNPLFLPLIPPQSQGFT
AIVLTYDRVESLFRVITEVSKVPSLSKLLVVWNNQNKNPPEDSLWPKIRV
PLKVVRTAENKLSNRFFPYDEIETEAVLAIDDDIIMLTSDELQFGYEVWR
EFPDRLVGYPGRLHLWDHEMNKWKYESEWTNEVSMVLTGAAFYHKYFNYL
YTYKMPGDIKNWVDAHMNCEDIAMNFLVANVTGKAVIKVTPRKKFKCPTH
MVERSECINKFASVFGTMPLKVVEHRADPVLYKDDFPEKLKSFPNIGS
3D structure
PDB7sck Structural basis for heparan sulfate co-polymerase action by the EXT1-2 complex.
ChainB
Resolution2.8 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.4.1.224: glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N- acetylglucosaminyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 BDP B R569 Y582 K653 R673 R462 Y475 K546 R554
BS02 UDP B L461 Y463 R465 D539 M624 L354 Y356 R358 D432 M517
Gene Ontology
Molecular Function
GO:0005515 protein binding
GO:0008375 acetylglucosaminyltransferase activity
GO:0015020 glucuronosyltransferase activity
GO:0016757 glycosyltransferase activity
GO:0042328 heparan sulfate N-acetylglucosaminyltransferase activity
GO:0042803 protein homodimerization activity
GO:0046872 metal ion binding
GO:0046982 protein heterodimerization activity
GO:0050508 glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity
GO:0050509 N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase activity
Biological Process
GO:0000271 polysaccharide biosynthetic process
GO:0001503 ossification
GO:0001707 mesoderm formation
GO:0002062 chondrocyte differentiation
GO:0006024 glycosaminoglycan biosynthetic process
GO:0006486 protein glycosylation
GO:0006487 protein N-linked glycosylation
GO:0008217 regulation of blood pressure
GO:0010467 gene expression
GO:0015012 heparan sulfate proteoglycan biosynthetic process
GO:0015014 heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process
GO:0030210 heparin biosynthetic process
GO:0042044 fluid transport
GO:0042311 vasodilation
GO:0044344 cellular response to fibroblast growth factor stimulus
GO:0050891 multicellular organismal-level water homeostasis
GO:0051923 sulfation
GO:0055078 sodium ion homeostasis
GO:0060047 heart contraction
GO:0060350 endochondral bone morphogenesis
Cellular Component
GO:0000139 Golgi membrane
GO:0005576 extracellular region
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0005794 Golgi apparatus
GO:0016020 membrane
GO:0043541 UDP-N-acetylglucosamine transferase complex
GO:0070062 extracellular exosome
GO:1902494 catalytic complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7sck, PDBe:7sck, PDBj:7sck
PDBsum7sck
PubMed36593275
UniProtQ93063|EXT2_HUMAN Exostosin-2 (Gene Name=EXT2)

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