Structure of PDB 7sbn Chain B

Receptor sequence
>7sbnB (length=405) Species: 9606 (Homo sapiens) [Search protein sequence]
LPSLEDLLFYTIAEQEKIPVHKFITALKSTGLRTSDPRLKECMDMLRLTL
QTTSGVMLDKDLFKKCVQSNIVLLTQAFRRKFVIPDFMSFTSHIDELYES
AKKQSGGKVADYIPQLAKFSPDLWGVSVCTVDGQRHSTGDTKVPFCLQSC
VKPLKYAIAVNDLGTEYVHRYVGKEPSGLLFLNEDDKPHNPMVNAGAIVV
TSLIKQGVNNAEKFDYVMQFLNKMAGNEYVGFSNATFQSERESGDRNFAI
GYYLKEKKCFPEGTDMVGILDFYFQLCSIEVTCESASVMAATLANGGFCP
ITGERVLSPEAVRNTLSLMHSCGMWDFSGQFAFHVGLPAKSGVAGGILLV
VPNVMGMMCWSPPLDKMGNSVKGIHFCHDLVSLCNFHNYDNLRHFAKKLD
PRREG
3D structure
PDB7sbn High-resolution structures of mitochondrial glutaminase C tetramers indicate conformational changes upon phosphate binding.
ChainB
Resolution2.14 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.5.1.2: glutaminase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 GLN B Y249 Q285 S286 N335 E381 N388 Y414 W466 G483 V484 Y112 Q148 S149 N194 E240 N247 Y273 W325 G342 V343
Gene Ontology
Molecular Function
GO:0004359 glutaminase activity
Biological Process
GO:0006541 glutamine metabolic process

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Molecular Function
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Biological Process
External links
PDB RCSB:7sbn, PDBe:7sbn, PDBj:7sbn
PDBsum7sbn
PubMed34999118
UniProtO94925|GLSK_HUMAN Glutaminase kidney isoform, mitochondrial (Gene Name=GLS)

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