Structure of PDB 7s6h Chain B

Receptor sequence
>7s6hB (length=469) Species: 9606 (Homo sapiens) [Search protein sequence]
AAVDPDSGLEHSAHVLEKGGKVFSATLGLVDIVKGTNSYYKLQLLEDDKE
NRYWIFRSWGRVGTVIGSNKLEQMPSKEDAIEHFMKLYEEKTGNAWHSKN
FTKYPKKFYPLEIDYGGTKSKLPKPVQDLIKMIFDVESMKKAMYEIDLQK
MPLGKLSKRQIQAAYSILSEVQQAVSQGSSDSQILDLSNRFYTLIPHDFG
MKKPPLLNNADSVQAKAEMLDNLLDIEVAYSLLRGGDPIDVNYEKLKTDI
KVVDRDSEEAEIIRKYVKNTHATTHNAYDLEVIDIFKIEREGECQRYKPF
KQLHNRRLLWHGSRTTNFAGILSQGLRIAPPEAPVTGYMFGKGIYFADMV
SKSANYCHTSQGDPIGLILLGEVALGNMYELKHASHISKLPKGKHSVKGL
GKTTPDPSANISLDGVDVPLGTGISSGVNDTSLLYNEYIVYDIAQVNLKY
LLKLKFNFKTSLWLEHHHH
3D structure
PDB7s6h Captured snapshots of PARP1 in the active state reveal the mechanics of PARP1 allostery.
ChainB
Resolution3.1 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.4.2.-
2.4.2.30: NAD(+) ADP-ribosyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna B Y570 R587 W589 K600 K621 Y40 R57 W59 K70 K91
BS02 UHB B H862 G863 S864 N868 G871 I872 R878 Y896 S904 Y907 H311 G312 S313 N317 G320 I321 R327 Y345 S353 Y356
Gene Ontology
Molecular Function
GO:0003950 NAD+-protein poly-ADP-ribosyltransferase activity

View graph for
Molecular Function
External links
PDB RCSB:7s6h, PDBe:7s6h, PDBj:7s6h
PDBsum7s6h
PubMed35793673
UniProtP09874|PARP1_HUMAN Poly [ADP-ribose] polymerase 1 (Gene Name=PARP1)

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