Structure of PDB 7s6c Chain B

Receptor sequence
>7s6cB (length=891) Species: 1836,324833 [Search protein sequence]
VTDSEKVAEYLRRATLDLRAARQRIRELESEPIAIIGMACRLPGGVDSPE
GLWELVDSGTDAIAGFPLDRGWDVEGMYDPDAEAPGKTYVKEAGFLYDAG
EFDAGFFGISPREAVSMDPQQRLMLEASWEAFERAGLDPARQRGTATGVF
VGATATGYVGFAITGNMTAVTSGRISYTLGLQGPAVTIDTACSSSLVALH
LACQSLRQGECTTALAGGVTVMPTPTAFTEFSRQRGLAPDGRCKSFAAAA
DGTNWAEGVAVLVVERLSDARRNGHRVLAVVRGTAINQDGASNGLSAPND
LAQERVIRSALDNAGLTASDVDAVEAHGTGTTLGDPIEAQALLAAYGHER
PAHRPLRVGSLKSNIGHAGPAAGVAGVIKMVMAMRHGVLPRSLHIDEPTP
QVDWSSGAVTLLTEPVDWPDSDRPRRAGVSAFGISGTNAHVILEQAPTQA
PPVPAAPWLLSAKTPAALRAQARRLHTHLARHPHPDPTDIAHALATTRTP
HEHRAALVTDDHGTRGPALAALAEGAPDACLISGTALSKGRTVFVFPGQG
SQWTGMGRELLHTSPEFAAYIAECETALNDFVDWSLTDVLRGTEGAPGYD
RVDVVQPALFAVMVSLARLWQHHGIHPDAVIGHSQGEIAAAHIAGALSLQ
DAARIVALRSQALLPLAGLGGMTSLALPHDQALQLIQPWGQDLSIASVNG
PHSTVVSGTTHALDELHTTCDTQGVRARRIPVDYASHSAQVESIRDTVLQ
AATGINPQPTTIPLYSTVTGQPIDGTQLDADYWYTNLRHTVRFEETTRAL
LGSGHRHFIETTAHPVLALALEETIEATGSDARVTGTLRRDHGDLTQLHT
ALATAWTHGIDVDWTAVLGDRRTPFELPTYAFQRQRYWLEP
3D structure
PDB7s6c Modular polyketide synthase contains two reaction chambers that operate asynchronously.
ChainB
Resolution3.1 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.3.1.94: 6-deoxyerythronolide-B synthase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 PNS B C210 S314 F450 I452 C192 S296 F432 I434
Gene Ontology
Molecular Function
GO:0004312 fatty acid synthase activity
GO:0004315 3-oxoacyl-[acyl-carrier-protein] synthase activity
GO:0016740 transferase activity
GO:0016746 acyltransferase activity
GO:0016747 acyltransferase activity, transferring groups other than amino-acyl groups
GO:0031177 phosphopantetheine binding
Biological Process
GO:0006633 fatty acid biosynthetic process
GO:0017000 antibiotic biosynthetic process
GO:0033068 macrolide biosynthetic process
GO:0071770 DIM/DIP cell wall layer assembly
Cellular Component
GO:0005737 cytoplasm
GO:0005886 plasma membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7s6c, PDBe:7s6c, PDBj:7s6c
PDBsum7s6c
PubMed34735234
UniProtB6ZK67;
Q03132|ERYA2_SACER 6-deoxyerythronolide-B synthase EryA2, modules 3 and 4 (Gene Name=eryA)

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