Structure of PDB 7s5h Chain B

Receptor sequence
>7s5hB (length=230) Species: 9606 (Homo sapiens) [Search protein sequence]
VEVYLLDTSIQSDHREIEGRVMVTDFENVPEETRFHRQASKCDSHGTHLA
GVVSGRDAGVAKGASMRSLRVLNCQGKGTVSGTLIGLEFIRKSQLVGPLV
VLLPLAGGYSRVLNAACQRLARAGVVLVTAAGNFRDDACLYSPASAPEVI
TVGATNAQDQPVGTNFGRCVDLFAPGEDIIGASSDCSTCFVSQSGTSQAA
AHVAGIAAMMLSAEPELTLAELRQRLIHFS
3D structure
PDB7s5h A Series of Novel, Highly Potent, and Orally Bioavailable Next-Generation Tricyclic Peptide PCSK9 Inhibitors.
ChainB
Resolution1.272 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.4.21.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide B D238 D367 I369 D374 T377 C378 F379 V380 S381 D57 D178 I180 D185 T188 C189 F190 V191 S192
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
GO:0008236 serine-type peptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:7s5h, PDBe:7s5h, PDBj:7s5h
PDBsum7s5h
PubMed34704436
UniProtQ8NBP7|PCSK9_HUMAN Proprotein convertase subtilisin/kexin type 9 (Gene Name=PCSK9)

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