Structure of PDB 7s2k Chain B

Receptor sequence
>7s2kB (length=261) Species: 77133 (uncultured bacterium) [Search protein sequence]
MNKSLIIFGIVNITYLAPDAAIAQARKLMAEGADVIDLGPASSNPDAAPV
SSDTEIARIAPVLDALKADGIPVSLDSYQPATQAYALSRGVAYLNDIRGF
PDAAFYPQLAKSSAKLVVMHSVQDGQADRREAPAGDIMDHIAAFFDARIA
ALTGAGIKRNRLVLDPGMGFFLGAAPETSLSVLARFDELRLRFDLPVLLS
VSRKSFLRALTGRGPGDVGAATLAAELAAAAGGADFIRTHEPRPLRDGLA
VLAALKETARI
3D structure
PDB7s2k Molecular mechanism of plasmid-borne resistance to sulfonamide antibiotics.
ChainB
Resolution1.74 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.5.1.15: dihydropteroate synthase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 78H B S52 D85 N104 M128 D174 G178 F179 F180 S209 K213 S214 R247 S43 D76 N95 M119 D165 G169 F170 F171 S200 K204 S205 R238
BS02 PAB B N53 R247 H249 N44 R238 H240
Gene Ontology
Molecular Function
GO:0004156 dihydropteroate synthase activity
GO:0016740 transferase activity
GO:0046872 metal ion binding
Biological Process
GO:0009396 folic acid-containing compound biosynthetic process
GO:0042558 pteridine-containing compound metabolic process
GO:0044237 cellular metabolic process
GO:0046654 tetrahydrofolate biosynthetic process
GO:0046656 folic acid biosynthetic process
GO:0046677 response to antibiotic
Cellular Component
GO:0005829 cytosol

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Cellular Component
External links
PDB RCSB:7s2k, PDBe:7s2k, PDBj:7s2k
PDBsum7s2k
PubMed37419898
UniProtP0AC11|DHP2_ECOLX Dihydropteroate synthase type-2 (Gene Name=sulII)

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