Structure of PDB 7s0z Chain B

Receptor sequence
>7s0zB (length=541) Species: 1496 (Clostridioides difficile) [Search protein sequence]
MSLVNRKQLEKMANVRFRVQEDEYVAILDALEEYHNMSENTVVEKYLKLK
DINSLTDTYIDTYKKSGRNKALKKFKEYLVIEILELKNSNLTPVEKNLHF
IWIGGQINDTAINYINQWKDVNSDYNVNVFYDSNAFLINTLKKTIIESAS
NDTLESFRENLNDPEFNHTAFFRKRMQIIYDKQQNFINYYKAQKEENPDL
IIDDIVKTYLSNEYSKDIDELNAYIEESLNKVTENSGNDVRNFEEFKTGE
VFNLYEQELVERWNLAGASDILRVAILKNIGGVYLDVDMLPGIHPDLFKD
INKPDSVKTAVDWEEMQLEAIMKHKEYIPEYTSKHFDTLDEEVQSSFESV
LASKSDKSEIFLPLGDIEVSPLEVKIAFAKGSIINQALISAKDSYCSDLL
IKQIQNRYKILNDTLGPIISQGNDFNTTMNNFGESLGAIANEENISFIAK
IGSYLRVGFYPEANTTITLSGPTIYAGAYKDLLTFKEMSIDTSILSSELR
NFEFPKVNISQATEQEKNSLWQFNEERAKIQFEEYKKNYFE
3D structure
PDB7s0z Structural basis for selective modification of Rho and Ras GTPases by Clostridioides difficile toxin B.
ChainB
Resolution2.34 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.4.1.-
3.4.22.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 UDP B I101 W102 I103 N139 L265 S269 D286 V287 D288 S519 L520 W521 I101 W102 I103 N139 L265 S269 D286 V287 D288 S519 L520 W521
BS02 MN B D288 E516 D288 E516
BS03 GLC B A266 D270 D286 N385 Q386 T466 G471 P472 W521 A266 D270 D286 N385 Q386 T466 G471 P472 W521
Gene Ontology
Molecular Function
GO:0016757 glycosyltransferase activity

View graph for
Molecular Function
External links
PDB RCSB:7s0z, PDBe:7s0z, PDBj:7s0z
PDBsum7s0z
PubMed34678063
UniProtQ9EXR0|TCDB2_CLODI Toxin B (Gene Name=tcdB)

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