Structure of PDB 7rx2 Chain B

Receptor sequence

>7rx2B (length=615) Species: 451804 (Aspergillus fumigatus A1163) [Search protein sequence]

QENHHVDYVIRFNYGDIDTPEAIKKFEVLLLELSEVGLQTEVRQGDENSL
FVFVRAASKKKLKRAVYQSRVRDWLYGVRNTEPEPASSAKPQSEAERLLV
IYHLITVPKAEGGAGITPRHGEWKNVDAIFPLHDEETNRQCMREWSKKTF
LSTEDLDRIRNTFGEHVGFYFAFLQSYFRFLMFPAAFGFSCWLLLGSFSI
IYTVVNCLWCIVFIEYWKRQEEDLSCRWQTKGVSAVHEKRAEFKPEKEIR
VRGVFPATKRMYRQLLQVPFALLAAVALGAIIATCFAIEIFISEVYNGPL
KGYLVFIPTILVSALIPTMSAVLLTVATKLNDYENYETQDAYKVALTQKI
FVVNFITSYLPIILTAFVYVPFASRIVPYLDFSINPDRLRKQVIYFTVTA
QIVGFALETIVPFVKEDEARFLTRVRNEAELEDYDVTDDLREMCIQFGYL
ALFSPVWPLVPVSFLINNWVELRSDFFKICVECKRPWPQRADTIGPWLDS
LGFLSWVGSITSSALVYMFSNGHEGPNGEPTTIRCWALLLTIFFSEHLYL
IVRYAVRSALAKLEPPNTRRERIERFMMRKRYLDTVLSPTERFWMRQRGW
KESAEVGLSLITKAK

3D structure

PDB

7rx2 TMEM16 scramblases thin the membrane to enable lipid scrambling.

Chain

Resolution

2.7 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	CA	B	E445 D511 E514 E543 D547	E408 D439 E442 E471 D475
BS02	CA	B	E445 E514 E543	E408 E442 E471
BS03	PGW	B	P602 C607	P530 C535
BS04	PGW	B	C217 Y589 S592 T604 R606 T613 F616 S617	C207 Y517 S520 T532 R534 T541 F544 S545
BS05	PGW	B	R189 F190 F193 L218 Y226	R179 F180 F183 L208 Y216
BS06	PGW	B	F367 D571 F575 W578 I582	F351 D499 F503 W506 I510
BS07	PGW	B	Y278 L281 L282	Y262 L265 L266
BS08	PGW	B	P285 F286 L289 Y349	P269 F270 L273 Y333
BS09	PGW	B	Y626 A627 K634	Y554 A555 K562
BS10	PGW	B	A287 Q364	A271 Q348
BS11	PGW	B	H619 Y626	H547 Y554

Gene Ontology

	Molecular Function
GO:0005245	voltage-gated calcium channel activity
GO:0005254	chloride channel activity
GO:0017128	phospholipid scramblase activity

	Biological Process
GO:0017121	plasma membrane phospholipid scrambling
GO:0034220	monoatomic ion transmembrane transport
GO:0045332	phospholipid translocation
GO:0070588	calcium ion transmembrane transport
GO:1902476	chloride transmembrane transport

	Cellular Component
GO:0016020	membrane
GO:0032541	cortical endoplasmic reticulum

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Molecular Function

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Biological Process

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Cellular Component

External links

PDB	RCSB:7rx2, PDBe:7rx2, PDBj:7rx2
PDBsum	7rx2
PubMed	35562175
UniProt	Q4WA18

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