Structure of PDB 7rot Chain B

Receptor sequence
>7rotB (length=352) Species: 36329 (Plasmodium falciparum 3D7) [Search protein sequence]
EKKAQEESKIEDVDKILNDILSISSECIQPDELRVKLLLKRKLICYDGFE
PSGRMHIAQGLLKSIIVNKLTSNGCTFIFWIADWFAHLNNKMSGDLKKIK
KVGSYFIEVWKSCGMNMENVQFLWASEEINKKPNEYWSLVLDISRSFNIN
RMKRCLKIMGRSEGEENYCSQILYPCMQCADIFFLNVDICQLGIDQRKVN
MLAREYCDIKKIKKKPVILCHGMLPGLLEGQDENSAIFMDDSESDVNRKI
KKAYCPPNVIENNPIYAYAKSIIFPSYNEFNLVRKEKNGGDKTYYTLQEL
EHDYVNGFIHPLDLKDNVAMYINKLLQPVRDHFQNNIEAKNLLNEIKKYK
VT
3D structure
PDB7rot Reaction hijacking of tyrosine tRNA synthetase as a new whole-of-life-cycle antimalarial strategy.
ChainB
Resolution2.2 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number 6.1.1.1: tyrosine--tRNA ligase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 66I B Y60 D61 G62 F63 E64 H70 A72 Q73 W94 F99 I172 Y188 Q192 D195 L206 G207 D209 Q210 H235 M237 L238 Y46 D47 G48 F49 E50 H56 A58 Q59 W80 F85 I158 Y174 Q178 D181 L192 G193 D195 Q196 H221 M223 L224
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0004812 aminoacyl-tRNA ligase activity
GO:0004831 tyrosine-tRNA ligase activity
GO:0005524 ATP binding
GO:0046789 host cell surface receptor binding
GO:0046872 metal ion binding
Biological Process
GO:0006412 translation
GO:0006418 tRNA aminoacylation for protein translation
GO:0006437 tyrosyl-tRNA aminoacylation
GO:0044650 adhesion of symbiont to host cell
Cellular Component
GO:0005737 cytoplasm
GO:0044164 host cell cytosol

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:7rot, PDBe:7rot, PDBj:7rot
PDBsum7rot
PubMed35653481
UniProtQ8IAR7

[Back to BioLiP]