Structure of PDB 7rk5 Chain B

Receptor sequence
>7rk5B (length=501) Species: 330879 (Aspergillus fumigatus Af293) [Search protein sequence]
APLKLNSRNLSQIAAAGGALVKIPTYQRGRAVKEGIVHIGVGGFHRAHLA
VYIDQLMQKHGVNDYAICGVGLQPFDSAMRDALASQDHLYTLIERSAKGS
FAHVIGSINSYLFAPDNREAVIAKMAHPDTKIVSLTITESGYYYNENTHE
LQSEHPDIQFDLDPANEKAPRTTFGFLYAGLTRRYQQGLKPFTVMSCDNM
QKNGSITRHMLESFARLRNPEVAEWIAEEGAFPNAMVDRITPQTSETDKT
ALAEKFGIVDSWPVVTEPFTQWVIEDQFSDGRPPFEKVGVQVVKHAVEQF
EKHKLRLLNGSHSALGYPGQLAGFQYVHEVMANPLFRKFVWQMMQEEVKP
LLPEIPGVDIDEYCNTLIERFTNPTIMDQLPRICLNASGKIPQFIMPSIA
EAIWETGPFRRLCFVAAAWFHYIKGVDDRGKPFEVVDPMREELQAKARAG
GNDPSELLSIKSLFGDDLRNDERFLREITTAMNDIARDGIMKTLPKYING
S
3D structure
PDB7rk5 Targeting the Mannitol Biosynthesis Pathway in Aspergillus fumigatus: Characterisation and Inhibition of Mannitol-2-Dehydrogenase
ChainB
Resolution2.1 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number 1.1.1.67: mannitol 2-dehydrogenase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 NAI B G41 V42 G43 G44 F45 Q74 D77 T137 I138 D199 N200 I241 T242 G40 V41 G42 G43 F44 Q73 D76 T136 I137 D198 N199 I240 T241
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0016491 oxidoreductase activity
GO:0046029 mannitol dehydrogenase activity
GO:0050086 mannitol 2-dehydrogenase activity
GO:0050661 NADP binding
GO:0051287 NAD binding
Biological Process
GO:0019594 mannitol metabolic process

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:7rk5, PDBe:7rk5, PDBj:7rk5
PDBsum7rk5
PubMed
UniProtQ4WQY4|M2DH_ASPFU Mannitol 2-dehydrogenase (Gene Name=AFUA_4G14450)

[Back to BioLiP]