Structure of PDB 7rgq Chain B

Receptor sequence

>7rgqB (length=481) Species: 9606 (Homo sapiens) [Search protein sequence]

GYVPEDGLTAQQLFASADGLTYNDFLILPGFIDFIADEVDLTSALTRKIT
LKTPLISSPMDTVTEADMAIAMALMGGIGFIHHNCTPEFQANEVRKVKKF
EQGFITDPVVLSPSHTVGDVLEAKMRHGFSGIPITETGTMGSKLVGIVTS
RDIDFDHTTLLSEVMTPRIELVVAPAGVTLKEANEILQRSKKGKLPIVND
CDELVAIIARTDLKKNRDYPLASKDSQKQLLCGAAVGTREDDKYRLDLLT
QAGVDVIVLDSSQGNSVYQIAMVHYIKQKYPHLQVIGGNVVTAAQAKNLI
DAGVDGLRVGMGCGSICITQEVMACGRPQGTAVYKVAEYARRFGVPIIAD
GGIQTVGHVVKALALGASTVMMGSLLAATTEAPGEYFFSDGVRLKKYRGM
GSLKIAQGVSGSIQDKGSIQKFVPYLIAGIQHGCQDIGARSLSVLRSMMY
SGELKFEKRTMSAQIEGGVHGLHSYTFLPFT

3D structure

PDB

7rgq IMPDH1 retinal variants control filament architecture to tune allosteric regulation.

Chain

Resolution

3.9 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

1.1.1.205: IMP dehydrogenase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	NAD	B	H466 Q469	H432 Q435
BS02	GTP	B	Q112 L194 N198 N230 K242	Q102 L180 N184 N216 K228
BS03	NAD	B	R253 D274 S275 S276 Y282 M414	R239 D260 S261 S262 Y268 M400
BS04	IMP	B	S68 M70 G328 S329 C331 D364 G365 G366 G387 S388 M414 G415	S58 M60 G314 S315 C317 D350 G351 G352 G373 S374 M400 G401
BS05	ATP	B	T159 R161 D162 L185 V186 K206 G207 K208	T149 R151 D152 L171 V172 K192 G193 K194
BS06	GTP	B	K109 F139 S140 K208 T225 D226	K99 F129 S130 K194 T211 D212

Gene Ontology

	Molecular Function
GO:0000166	nucleotide binding
GO:0003676	nucleic acid binding
GO:0003677	DNA binding
GO:0003723	RNA binding
GO:0003824	catalytic activity
GO:0003938	IMP dehydrogenase activity
GO:0016491	oxidoreductase activity
GO:0046872	metal ion binding

	Biological Process
GO:0006164	purine nucleotide biosynthetic process
GO:0006177	GMP biosynthetic process
GO:0006183	GTP biosynthetic process

	Cellular Component
GO:0005576	extracellular region
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0034774	secretory granule lumen
GO:0035578	azurophil granule lumen
GO:1904813	ficolin-1-rich granule lumen

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Molecular Function

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Cellular Component

External links

PDB	RCSB:7rgq, PDBe:7rgq, PDBj:7rgq
PDBsum	7rgq
PubMed	35013599
UniProt	P20839\|IMDH1_HUMAN Inosine-5'-monophosphate dehydrogenase 1 (Gene Name=IMPDH1)

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