Structure of PDB 7rgm Chain B

Receptor sequence

>7rgmB (length=484) Species: 9606 (Homo sapiens) [Search protein sequence]

GYVPEDGLTAQQLFASADGLTYNDFLILPGFIDFIADEVDLTSALTRKIT
LKTPLISSPMDTVTEADMAIAMALMGGIGFIHHNCTPEFQANEVRKVKKF
EQGFITDPVVLSPSHTVGDVLEAKMRHGFSGIPITETGTMGSKLVGIVTS
RDIDFLAEKDHTTLVMTPRIELVVAPAGVTLKEANEILQRSKKGKLPIVN
DCDELVAIIARTDLKKNRDYPLASKDSQKQLLCGAAVGTREDDKYRLDLL
TQAGVDVIVLDSSQGNSVYQIAMVHYIKQKYPHLQVIGGNVVTAAQAKNL
IDAGVDGLRVGMGCGSICITQEVMACGRPQGTAVYKVAEYARRFGVPIIA
DGGIQTVGHVVKALALGASTVMMGSLLAATTEAPGEYFFSDGVRLKKYRG
MGSLDAMEKVKIAQGVSGSIQDKGSIQKFVPYLIAGIQHGCQDIGARSLS
VLRSMMYSGELKFEKRTMSAQIEGGVHGLHSYTF

3D structure

PDB

7rgm IMPDH1 retinal variants control filament architecture to tune allosteric regulation.

Chain

Resolution

2.8 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

1.1.1.205: IMP dehydrogenase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	ATP	B	T159 S160 R161 D162 T180 L185 V186 K206 G207	T149 S150 R151 D152 T167 L172 V173 K193 G194
BS02	ATP	B	I115 P118 V119 F139 S140 G141 K208 T225 D226	I105 P108 V109 F129 S130 G131 K195 T212 D213
BS03	IMP	B	S68 M70 R322 G328 S329 I330 C331 D364 G387 S388 Y411 G413 M414 G415 Q441 G442	S58 M60 R309 G315 S316 I317 C318 D351 G374 S375 Y398 G400 M401 G402 Q414 G415
BS04	NAD	B	T252 R253 D274 S275 S276 Y282 C331 T333 M414	T239 R240 D261 S262 S263 Y269 C318 T320 M401
BS05	ATP	B	R161 K205	R151 K192

Gene Ontology

	Molecular Function
GO:0000166	nucleotide binding
GO:0003676	nucleic acid binding
GO:0003677	DNA binding
GO:0003723	RNA binding
GO:0003824	catalytic activity
GO:0003938	IMP dehydrogenase activity
GO:0016491	oxidoreductase activity
GO:0046872	metal ion binding

	Biological Process
GO:0006164	purine nucleotide biosynthetic process
GO:0006177	GMP biosynthetic process
GO:0006183	GTP biosynthetic process

	Cellular Component
GO:0005576	extracellular region
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0034774	secretory granule lumen
GO:0035578	azurophil granule lumen
GO:1904813	ficolin-1-rich granule lumen

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Molecular Function

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Biological Process

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Cellular Component

External links

PDB	RCSB:7rgm, PDBe:7rgm, PDBj:7rgm
PDBsum	7rgm
PubMed	35013599
UniProt	P20839\|IMDH1_HUMAN Inosine-5'-monophosphate dehydrogenase 1 (Gene Name=IMPDH1)

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