Structure of PDB 7rec Chain B

Receptor sequence
>7recB (length=131) Species: 9606 (Homo sapiens) [Search protein sequence]
VRKQEIIKVNQQLIEAISNGDFESYTKMCDPGMTAFEPEALGNLVEGLDF
HRFYFENLWSRNSKPVHNTMLNPHIHLMGDESACIAYIRITQYLDAGGIP
RTAQSEETRVWHRRDGKWQHVHMHRSGAPSV
3D structure
PDB7rec GHB analogs confer neuroprotection through specific interaction with the CaMKII alpha hub domain.
ChainB
Resolution2.2 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.11.17: calcium/calmodulin-dependent protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 7ZV B I361 Y369 E381 H395 Y398 R453 M467 R469 S474 I17 Y25 E37 H51 Y54 R109 M123 R125 S130
Gene Ontology
Molecular Function
GO:0004683 calcium/calmodulin-dependent protein kinase activity
GO:0005516 calmodulin binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:7rec, PDBe:7rec, PDBj:7rec
PDBsum7rec
PubMed34330837
UniProtQ9UQM7|KCC2A_HUMAN Calcium/calmodulin-dependent protein kinase type II subunit alpha (Gene Name=CAMK2A)

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