Structure of PDB 7rct Chain B

Receptor sequence
>7rctB (length=501) Species: 9606 (Homo sapiens) [Search protein sequence]
SRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVT
HIKIQNTGDYYDLYGGEKFATLAELVQYYMEHHGQLKENGDVIELKYPLN
CADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRT
GDDKNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETL
GTVLQLKQPLNTTRINAAEIESRVRELSKLQGFWEEFETLQQQECKLLYS
RKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEK
KSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDE
YALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWP
DHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDI
LIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIET
L
3D structure
PDB7rct Targeted Degradation of the Oncogenic Phosphatase SHP2.
ChainB
Resolution1.8 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.1.3.48: protein-tyrosine-phosphatase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 4Q4 B T108 E110 R111 F113 L216 T218 T219 E249 E250 T253 L254 Q257 P491 K492 Q495 T105 E107 R108 F110 L210 T212 T213 E235 E236 T239 L240 Q243 P467 K468 Q471
Gene Ontology
Molecular Function
GO:0004725 protein tyrosine phosphatase activity
Biological Process
GO:0006470 protein dephosphorylation
GO:0016311 dephosphorylation

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Molecular Function
View graph for
Biological Process
External links
PDB RCSB:7rct, PDBe:7rct, PDBj:7rct
PDBsum7rct
PubMed34411482
UniProtQ06124|PTN11_HUMAN Tyrosine-protein phosphatase non-receptor type 11 (Gene Name=PTPN11)

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