Structure of PDB 7rci Chain B

Receptor sequence
>7rciB (length=295) Species: 9606 (Homo sapiens) [Search protein sequence]
LSLSTAVKELVENSLDAGATNIDLKLKDYGVDLIEVSDNGCGVEEENFEG
LTEALSSLCALSDVTISTCHASAKVGTRLMFDHNGKIIQKTPYPRPRGTT
VSVQQLFSTLPVRHKEFQRNIKKEYAKMVQVLHAYCIISAGIRVSCTNQL
GQGKRQPVVCTGGSPSIKENIGSVFGQKQLQSLIPFVQLPPSDSVCEEYG
LSCSDALHNLFYISGFISQCTHGVGRSSTDRQFFFINRRPCDPAKVCRLV
NEVYHMYNRHQYPFVVLNISVDSECLQEEKLLLAVLKTSLIGMFD
3D structure
PDB7rci PMS2 variant results in loss of ATPase activity without compromising mismatch repair.
ChainB
Resolution2.12 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.1.-.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ATP B N45 A49 L83 E109 A110 L111 N13 A17 L51 E53 A54 L55
Gene Ontology
Molecular Function
GO:0005524 ATP binding
GO:0016887 ATP hydrolysis activity
GO:0030983 mismatched DNA binding
GO:0140664 ATP-dependent DNA damage sensor activity
Biological Process
GO:0006298 mismatch repair
Cellular Component
GO:0032300 mismatch repair complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7rci, PDBe:7rci, PDBj:7rci
PDBsum7rci
PubMed35189042
UniProtP54278|PMS2_HUMAN Mismatch repair endonuclease PMS2 (Gene Name=PMS2)

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