Structure of PDB 7r9p Chain B

Receptor sequence
>7r9pB (length=291) Species: 9606 (Homo sapiens) [Search protein sequence]
VVDPDIFNRDPRDHYDLLQRLGGGTYGEVFKARDKVSGDLVALKMVKMEP
DDDVSTLQKEILILKTCRHANIVAYHGSYLWLQKLWICMEFCGAGSLQDI
YQVTGSLSELQISYVCREVLQGLAYLHSQKKIHRDIKGANILINDAGEVR
LADFGISAQIGAELARRLEFIGTPYWMAPEVAAVALKGGYNELCDIWSLG
ITAIELAELQPPLFDVHPLRVLFLMTKSGYQPPRLKEKGKWSAAFHNFIK
VTLTKSPKKRPSATKMLSHQLVSQPGLNRGLILDLLDKLKN
3D structure
PDB7r9p Discovery of Spiro-azaindoline Inhibitors of Hematopoietic Progenitor Kinase 1 (HPK1).
ChainB
Resolution2.27 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 2WI B L23 G24 Y28 V31 A44 M91 C94 G95 G97 D101 L144 L21 G22 Y26 V29 A42 M89 C92 G93 G95 D99 L142
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:7r9p, PDBe:7r9p, PDBj:7r9p
PDBsum7r9p
PubMed35059127
UniProtQ92918|M4K1_HUMAN Mitogen-activated protein kinase kinase kinase kinase 1 (Gene Name=MAP4K1)

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