Structure of PDB 7r9n Chain B

Receptor sequence
>7r9nB (length=286) Species: 9606 (Homo sapiens) [Search protein sequence]
VDPDIFNRDPRDHYDLLQRLGGGTYGEVFKARDKVSGDLVALKMVKDDVS
TLQKEILILKTCRHANIVAYHGSYLWLQKLWICMEFCGAGSLQDIYQVTG
SLSELQISYVCREVLQGLAYLHSQKKIHRDIKGANILINDAGEVRLADFG
ISAQIGAELARRLEFIGTPYWMAPEVAAVALKGGYNELCDIWSLGITAIE
LAELQPPLFDVHPLRVLFLMTKSGYQPPRLKEKGKWSAAFHNFIKVTLTK
SPKKRPSATKMLSHQLVSQPGLNRGLILDLLDKLKN
3D structure
PDB7r9n Discovery of Spiro-azaindoline Inhibitors of Hematopoietic Progenitor Kinase 1 (HPK1).
ChainB
Resolution1.5 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 F97 B L23 G24 A44 M91 C94 G97 L144 L20 G21 A41 M84 C87 G90 L137
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:7r9n, PDBe:7r9n, PDBj:7r9n
PDBsum7r9n
PubMed35059127
UniProtQ92918|M4K1_HUMAN Mitogen-activated protein kinase kinase kinase kinase 1 (Gene Name=MAP4K1)

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